IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i21p7020-d1273953.html
   My bibliography  Save this article

Occupational Etiology of Oropharyngeal Cancer: A Literature Review

Author

Listed:
  • Rayan Nikkilä

    (Department of Otorhinolaryngology—Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, FI-00139 Helsinki, Finland
    Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland)

  • Suvi Tolonen

    (Department of Otorhinolaryngology—Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland)

  • Tuula Salo

    (Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, FI-00014 Helsinki, Finland
    Translational Immunology Research Program (TRIMM), University of Helsinki, FI-00014 Helsinki, Finland
    Research Unit of Population Health, University of Oulu, FI-90014 Oulu, Finland
    Medical Research Centre Oulu, Oulu University Hospital, University of Oulu, FI-90220 Oulu, Finland)

  • Timo Carpén

    (Department of Otorhinolaryngology—Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland
    Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland
    Department of Pathology, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland)

  • Eero Pukkala

    (Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, FI-00139 Helsinki, Finland
    Health Sciences Unit, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland)

  • Antti Mäkitie

    (Department of Otorhinolaryngology—Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland
    Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland
    Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Hospital, Karolinska Institutet, SE-17177 Stockholm, Sweden)

Abstract

While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders.

Suggested Citation

  • Rayan Nikkilä & Suvi Tolonen & Tuula Salo & Timo Carpén & Eero Pukkala & Antti Mäkitie, 2023. "Occupational Etiology of Oropharyngeal Cancer: A Literature Review," IJERPH, MDPI, vol. 20(21), pages 1-13, November.
  • Handle: RePEc:gam:jijerp:v:20:y:2023:i:21:p:7020-:d:1273953
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/21/7020/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/20/21/7020/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Montserrat Alonso-Sardón & Antonio-J Chamorro & Ignacio Hernández-García & Helena Iglesias-de-Sena & Helena Martín-Rodero & Cristian Herrera & Miguel Marcos & José Antonio Mirón-Canelo, 2015. "Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-16, July.
    2. Maria Grazia Riccelli & Matteo Goldoni & Diana Poli & Paola Mozzoni & Delia Cavallo & Massimo Corradi, 2020. "Welding Fumes, a Risk Factor for Lung Diseases," IJERPH, MDPI, vol. 17(7), pages 1-32, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Eun-Woo Cha & Doosoo Jeon & Dongmug Kang & Young-Ki Kim & Se-Yeong Kim, 2022. "Chemical Pneumonitis Caused by the Inhalation of Zinc Oxide Fumes in an Arc Welder," IJERPH, MDPI, vol. 19(13), pages 1-7, June.
    2. Justyna Szulc & Anna Otlewska & Małgorzata Okrasa & Katarzyna Majchrzycka & Michael Sulyok & Beata Gutarowska, 2017. "Microbiological Contamination at Workplaces in a Combined Heat and Power (CHP) Station Processing Plant Biomass," IJERPH, MDPI, vol. 14(1), pages 1-18, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:21:p:7020-:d:1273953. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.