IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2022i1p646-d1019875.html
   My bibliography  Save this article

Clinical Outcomes Associated with SARS-CoV-2 Co-Infection with Rhinovirus and Adenovirus in Adults—A Retrospective Matched Cohort Study

Author

Listed:
  • Quynh-Lam Tran

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA)

  • Gregorio Benitez

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

  • Fadi Shehadeh

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece)

  • Matthew Kaczynski

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

  • Eleftherios Mylonakis

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

Abstract

(1) Background: Respiratory co-infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses are common, but data on clinical outcomes and laboratory biomarkers indicative of disease severity are limited. We aimed to compare clinical outcomes and laboratory biomarkers of patients with SARS-CoV-2 alone to those of patients with SARS-CoV-2 and either rhinovirus or adenovirus. (2) Methods: Hospitalized patients co-infected with SARS-CoV-2 and rhinovirus and patients co-infected with SARS-CoV-2 and adenovirus were matched to patients infected with SARS-CoV-2 alone. Outcomes of interest were the cumulative incidences of mechanical ventilation use, intensive care unit (ICU) admission, 30-day all-cause mortality, and 30-day all-cause readmission from the day of discharge. We also assessed differences in laboratory biomarkers from the day of specimen collection. (3) Results: Patients co-infected with SARS-CoV-2 and rhinovirus, compared with patients infected with SARS-CoV-2, had significantly greater 30-day all-cause mortality (8/23 (34.8%) vs. 8/69 (11.6%), p = 0.02). Additionally, median alanine transaminase (13 IU/L vs. 24 IU/L, p = 0.03), aspartate transaminase (25 IU/L vs. 36 IU/L, p = 0.04), and C-reactive protein (34.86 mg/L vs. 94.68 mg/L, p = 0.02) on day of specimen collection were significantly lower in patients co-infected with SARS-CoV-2 and rhinovirus in comparison to patients infected with SARS-CoV-2 alone. Clinical outcomes and laboratory markers did not differ significantly between patients with SARS-CoV-2 and adenovirus co-infection and patients with SARS-CoV-2 mono-infection. (4) Conclusion: SARS-CoV-2 and rhinovirus co-infection, compared with SARS-CoV-2 mono-infection alone, is positively associated with 30-day all-cause mortality among hospitalized patients. However, our lack of significant findings in our analysis of patients with SARS-CoV-2 and adenovirus co-infection may suggest that SARS-CoV-2 co-infections have variable significance, and further study is warranted.

Suggested Citation

  • Quynh-Lam Tran & Gregorio Benitez & Fadi Shehadeh & Matthew Kaczynski & Eleftherios Mylonakis, 2022. "Clinical Outcomes Associated with SARS-CoV-2 Co-Infection with Rhinovirus and Adenovirus in Adults—A Retrospective Matched Cohort Study," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    • Handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:646-:d:1019875
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/1/646/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/1/646/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ho, Daniel & Imai, Kosuke & King, Gary & Stuart, Elizabeth A., 2011. "MatchIt: Nonparametric Preprocessing for Parametric Causal Inference," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 42(i08).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chervier, Colas & Le Velly, Gwenolé & Ezzine-de-Blas, Driss, 2019. "When the Implementation of Payments for Biodiversity Conservation Leads to Motivation Crowding-out: A Case Study From the Cardamoms Forests, Cambodia," Ecological Economics, Elsevier, vol. 156(C), pages 499-510.
    2. Moritz Flubacher & George Sheldon & Adrian Müller, 2015. "Comparison of the Economic Performance between Organic and Conventional Dairy Farms in the Swiss Mountain Region Using Matching and Stochastic Frontier Analysis," Journal of Socio-Economics in Agriculture (Until 2015: Yearbook of Socioeconomics in Agriculture), Swiss Society for Agricultural Economics and Rural Sociology, vol. 7(1), pages 76-84.
    3. Akoh Fabien Yao & Maxime Sèbe & Laura Recuero Virto & Abdelhak Nassiri & Hervé Dumez, 2024. "The effect of LNG bunkering on port competitiveness using multilevel data analysis [L'effet du soutage par GNL sur la compétitivité des ports à l'aide de l'analyse de données à plusieurs niveaux]," Post-Print hal-04611804, HAL.
    4. Rigdon, Joseph & Berkowitz, Seth A. & Seligman, Hilary K. & Basu, Sanjay, 2017. "Re-evaluating associations between the Supplemental Nutrition Assistance Program participation and body mass index in the context of unmeasured confounders," Social Science & Medicine, Elsevier, vol. 192(C), pages 112-124.
    5. Rongtao Jiang & Stephanie Noble & Matthew Rosenblatt & Wei Dai & Jean Ye & Shu Liu & Shile Qi & Vince D. Calhoun & Jing Sui & Dustin Scheinost, 2024. "The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    6. Finocchiaro Castro, Massimo & Guccio, Calogero & Rizzo, Ilde, 2023. "How "one-size-fits-all" public works contract does it better? An assessment of infrastructure provision in Italy," EconStor Preprints 270729, ZBW - Leibniz Information Centre for Economics.
    7. Lo, A. W.-T. & Houston, D., 2018. "How do compact, accessible, and walkable communities promote gender equality in spatial behavior?," Journal of Transport Geography, Elsevier, vol. 68(C), pages 42-54.
    8. Stjepan Srhoj & Michael Lapinski & Janette Walde, 2019. "Size matters? Impact evaluation of business development grants on SME performance," Working Papers 2019-14, Faculty of Economics and Statistics, Universität Innsbruck.
    9. Jiaming Zeng & Michael F. Gensheimer & Daniel L. Rubin & Susan Athey & Ross D. Shachter, 2022. "Uncovering interpretable potential confounders in electronic medical records," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    10. Dong, Hongwei, 2017. "Rail-transit-induced gentrification and the affordability paradox of TOD," Journal of Transport Geography, Elsevier, vol. 63(C), pages 1-10.
    11. Peter Psathas, 2024. "Top of the Class Assessing the Credit Performance of Graduates from Secured Credit Card Programs," Consumer Finance Institute discussion papers DP24-02, Federal Reserve Bank of Philadelphia.
    12. Chen, Shanting & Mallory, Allen B., 2021. "The effect of racial discrimination on mental and physical health: A propensity score weighting approach," Social Science & Medicine, Elsevier, vol. 285(C).
    13. Katie Devenish & Sébastien Desbureaux & Simon Willcock & Julia P. G. Jones, 2022. "On track to achieve no net loss of forest at Madagascar’s biggest mine," Nature Sustainability, Nature, vol. 5(6), pages 498-508, June.
    14. Changjun Gu & Pei Zhao & Qiong Chen & Shicheng Li & Lanhui Li & Linshan Liu & Yili Zhang, 2020. "Forest Cover Change and the Effectiveness of Protected Areas in the Himalaya since 1998," Sustainability, MDPI, vol. 12(15), pages 1-24, July.
    15. Häusler, Mara-Magdalena & Zabel, Astrid, 2024. "Sites side by side: Can an agglomeration bonus with an adjacency rule connect agri-environmental sites?," Ecological Economics, Elsevier, vol. 224(C).
    16. Leite, Walter & Zhang, Huibin & collier, zachary & Chawla, Kamal & , l.kong@ufl.edu & Lee, Yongseok & Quan, Jia & Soyoye, Olushola, 2024. "Machine Learning for Propensity Score Estimation: A Systematic Review and Reporting Guidelines," OSF Preprints gmrk7, Center for Open Science.
    17. Arne Lauer & Samantha L. Speroni & Myoung Choi & Xiao Da & Christine Duncan & Siobhan McCarthy & Vijai Krishnan & Cole A. Lusk & David Rohde & Mikkel Bo Hansen & Jayashree Kalpathy-Cramer & Daniel J. , 2023. "Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    18. Maekawa, Wakako, 2024. "United Nations peacekeeping operations and multilateral foreign aid: Credibility of good governance," World Development, Elsevier, vol. 176(C).
    19. Mei-Cheng Wang & Yuxin Zhu, 2022. "Bias correction via outcome reassignment for cross-sectional data with binary disease outcome," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(4), pages 659-674, October.
    20. Schneeberger, Andres R. & Huber, Christian G. & Lang, Undine E. & Muenzenmaier, Kristina H. & Castille, Dorothy & Jaeger, Matthias & Seixas, Azizi & Sowislo, Julia & Link, Bruce G., 2017. "Effects of assisted outpatient treatment and health care services on psychotic symptoms," Social Science & Medicine, Elsevier, vol. 175(C), pages 152-160.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:646-:d:1019875. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.