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Liver and Renal Function Tests in Artisans Occupationally Exposed to Lead in Mechanic Village in Nnewi, Nigeria

Author

Listed:
  • C. E. Dioka

    (Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria)

  • O. E. Orisakwe

    (Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, P.M.B 5001, Nnewi, Anambra State, Nigeria)

  • F. A.A. Adeniyi

    (Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria)

  • S. C. Meludu

    (Dept of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, P.M.B 5001, Nnewi, Anambra State, Nigeria)

Abstract

Additives in petroleum solvents have been reported to have adverse health implications. An evaluation study on some toxicological effects of occupational exposure to petroleum products (especially petrol which contains tetraethyl lead) amongst twenty five occupationally exposed artisans and twenty five graduate students of College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria as controls, was carried out using the following biochemical markers: electrolytes, urea, uric acid, inorganic phosphorus, creatinine, zinc and blood lead, as well as the activities of alanine and aspartate aminotransferases, and alkaline phosphatase. The results showed that occupational exposure of human subjects to lead in petrol increases the concentrations of uric acid (357 ± 123μ mol/L) and phosphate (1.5 ± 0.5m mol/L) in exposed subjects compared with unexposed subjects (uric acid 228 ± 105μ mol/L, phosphate 1.2 ± 0.41m mol/L; p

Suggested Citation

  • C. E. Dioka & O. E. Orisakwe & F. A.A. Adeniyi & S. C. Meludu, 2004. "Liver and Renal Function Tests in Artisans Occupationally Exposed to Lead in Mechanic Village in Nnewi, Nigeria," IJERPH, MDPI, vol. 1(1), pages 1-5, February.
    • Handle: RePEc:gam:jijerp:v:1:y:2004:i:1:p:21-25:d:2785
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    Cited by:

    1. Saruda Kuraeiad & Manas Kotepui, 2021. "Blood Lead Level and Renal Impairment among Adults: A Meta-Analysis," IJERPH, MDPI, vol. 18(8), pages 1-33, April.

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