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The Effects of Alcohol Drinking on Oral Microbiota in the Chinese Population

Author

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  • Ying Liao

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
    These authors contributed equally to this work.)

  • Xia-Ting Tong

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
    School of Public Health, Sun Yat-sen University, Guangzhou 510062, China
    These authors contributed equally to this work.)

  • Yi-Jing Jia

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
    School of Public Health, Sun Yat-sen University, Guangzhou 510062, China)

  • Qiao-Yun Liu

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
    School of Public Health, Sun Yat-sen University, Guangzhou 510062, China)

  • Yan-Xia Wu

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Wen-Qiong Xue

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Yong-Qiao He

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Tong-Min Wang

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Xiao-Hui Zheng

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Mei-Qi Zheng

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

  • Wei-Hua Jia

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
    School of Public Health, Sun Yat-sen University, Guangzhou 510062, China)

Abstract

The dysbiosis of oral microbiota is linked to numerous diseases and is associated with personal lifestyles, such as alcohol drinking. However, there is inadequate data to study the effect of alcohol drinking on oral microbiota from the Chinese population. Here, we profiled the oral microbiota of 150 healthy subjects in the Chinese population by 16S rRNA gene sequencing. The results showed that drinkers had significantly higher alpha diversity than non-drinkers. A significant difference in overall microbiota composition was observed between non-drinkers and drinkers. Additionally, using DESeq analysis, we found genus Prevotella and Moryella , and species Prevotella melaninogenica and Prevotella tannerae were significantly enriched in drinkers; meanwhile, the genus Lautropia , Haemophilus and Porphyromonas , and species Haemophilus parainfluenzae were significantly depleted in drinkers. PICRUSt analysis showed that significantly different genera were mainly related to metabolism pathways. The oxygen-independent pathways, including galactose, fructose and mannose metabolism pathways, were enriched in drinkers and positively associated with genera enriched in drinkers; while the pyruvate metabolism pathway, an aerobic metabolism pathway, was decreased in drinkers and negatively associated with genera enriched in drinkers. Our results suggested that alcohol drinking may affect health by altering oral microbial composition and potentially affecting microbial functional pathways. These findings may have implications for better understanding the potential role those oral bacteria play in alcohol-related diseases.

Suggested Citation

  • Ying Liao & Xia-Ting Tong & Yi-Jing Jia & Qiao-Yun Liu & Yan-Xia Wu & Wen-Qiong Xue & Yong-Qiao He & Tong-Min Wang & Xiao-Hui Zheng & Mei-Qi Zheng & Wei-Hua Jia, 2022. "The Effects of Alcohol Drinking on Oral Microbiota in the Chinese Population," IJERPH, MDPI, vol. 19(9), pages 1-12, May.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:9:p:5729-:d:810926
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    References listed on IDEAS

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    1. Mary Rodríguez-Rabassa & Pablo López & Raphael Sánchez & Cyanela Hernández & Cesarly Rodríguez & Ronald E. Rodríguez-Santiago & Juan C. Orengo & Vivian Green & Yasuhiro Yamamura & Vanessa Rivera-Amill, 2020. "Inflammatory Biomarkers, Microbiome, Depression, and Executive Dysfunction in Alcohol Users," IJERPH, MDPI, vol. 17(3), pages 1-24, January.
    2. Tadashi Takeuchi & Eiji Miyauchi & Takashi Kanaya & Tamotsu Kato & Yumiko Nakanishi & Takashi Watanabe & Toshimori Kitami & Takashi Taida & Takaharu Sasaki & Hiroki Negishi & Shu Shimamoto & Akinobu M, 2021. "Acetate differentially regulates IgA reactivity to commensal bacteria," Nature, Nature, vol. 595(7868), pages 560-564, July.
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