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Frequency of Asbestos Exposure and Histological Subtype of Ovarian Carcinoma

Author

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  • Pauline Vidican

    (Département Prévention Cancer Environnement, Centre Léon Bérard, 28 Rue Laennec, CEDEX 08, 69373 Lyon, France
    These authors have contributed equally to this work and share first authorship.)

  • Olivia Perol

    (Département Prévention Cancer Environnement, Centre Léon Bérard, 28 Rue Laennec, CEDEX 08, 69373 Lyon, France
    Inserm UMR1296, “Radiations: Défense, Santé, Environnement”, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
    These authors have contributed equally to this work and share first authorship.)

  • Joëlle Fevotte

    (Université de Lyon, Université Lyon 1, Université Gustave Eiffel—Ifsttar, Umrestte, UMR T 9405, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France)

  • Emmanuel Fort

    (Université de Lyon, Université Lyon 1, Université Gustave Eiffel—Ifsttar, Umrestte, UMR T 9405, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France)

  • Isabelle Treilleux

    (Département D’anatomopathologie, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France)

  • Elodie Belladame

    (Département Prévention Cancer Environnement, Centre Léon Bérard, 28 Rue Laennec, CEDEX 08, 69373 Lyon, France)

  • Jiri Zavadil

    (Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, 150 Cours Albert Thomas, CEDEX 08, 69372 Lyon, France)

  • Béatrice Fervers

    (Département Prévention Cancer Environnement, Centre Léon Bérard, 28 Rue Laennec, CEDEX 08, 69373 Lyon, France
    Inserm UMR1296, “Radiations: Défense, Santé, Environnement”, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
    Faculté de médecine Lyon Est, Université de Lyon, Université Lyon 1, 8 Avenue Rockefeller, 69008 Lyon, France)

  • Barbara Charbotel

    (Université de Lyon, Université Lyon 1, Université Gustave Eiffel—Ifsttar, Umrestte, UMR T 9405, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France
    CRPPE-Lyon, Centre Régional de Pathologies Professionnelles et Environnementales de Lyon, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France)

Abstract

The International Agency for Research on Cancer established a causal link between asbestos exposure and ovarian cancer. However, the exposure frequency and histological characteristics of asbestos-associated ovarian cancers remain to be investigated in detail. This multicenter case–case study assessed the asbestos exposure in ovarian carcinoma (OC) patients, alongside its association with histological subtype. Women were recruited in four hospitals in Lyon, France. Histological reports were reviewed by a pathologist. Patient and family members’ data were collected by phone-based questionnaires. Asbestos exposure was defined as direct (occupational and environmental) and indirect (via parents, partners, and children). An industrial hygienist assessed the probability and level of exposure. The 254 enrolled patients (mean age 60 years) reported having an average of 2.3 different jobs (mean working duration 29 years). The prevalence of direct and indirect asbestos exposure was 13% (mean exposure duration 11 years) and 46%, respectively. High-grade serous carcinoma accounted for 73% of all OCs and 82% of histological subtypes in women with direct exposure. After adjustment on a familial history of OC, no significant associations between asbestos exposure (direct and/or indirect) and high-grade serous carcinoma were found. Women with OC had a high prevalence of asbestos exposure. Establishing risk profiles, as reported here, is important in facilitating compensation for asbestos-related OCs and for the surveillance of women at risk.

Suggested Citation

  • Pauline Vidican & Olivia Perol & Joëlle Fevotte & Emmanuel Fort & Isabelle Treilleux & Elodie Belladame & Jiri Zavadil & Béatrice Fervers & Barbara Charbotel, 2022. "Frequency of Asbestos Exposure and Histological Subtype of Ovarian Carcinoma," IJERPH, MDPI, vol. 19(9), pages 1-15, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:9:p:5383-:d:804708
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    References listed on IDEAS

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    1. Chunpeng Wang & Zhenzhen Liang & Xin Liu & Qian Zhang & Shuang Li, 2016. "The Association between Endometriosis, Tubal Ligation, Hysterectomy and Epithelial Ovarian Cancer: Meta-Analyses," IJERPH, MDPI, vol. 13(11), pages 1-12, November.
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