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Delayed Neurological Sequelae Successfully Treated with Adjuvant, Prolonged Hyperbaric Oxygen Therapy: Review and Case Report

Author

Listed:
  • Luca Martani

    (Vaio Hospital, 43036 Fidenza, Italy)

  • Andrea Giovanniello

    (Casa di Cura HABILITA I Cedri, 28073 Fara Novarese, Italy)

  • Gerardo Bosco

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Luca Cantadori

    (Vaio Hospital, 43036 Fidenza, Italy)

  • Francesca Calissi

    (Rivoli Hospital, 10098 Rivoli, Italy)

  • Dany Furfaro

    (Ospedale Parini, 11100 Aosta, Italy)

  • Massimo Pedrazzini

    (Vaio Hospital, 43036 Fidenza, Italy)

  • Rosanna Vaschetto

    (Department of Translational Sciences, University of Eastern Piedmont, 28100 Novara, Italy)

  • Enrico Mario Camporesi

    (Department of Surgery, University of South Florida, Tampa, FL 33606, USA)

  • Matteo Paganini

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

Abstract

Carbon Monoxide (CO) intoxication is still a leading cause of mortality and morbidity in many countries. Due to the problematic detection in the environment and subtle symptoms, CO intoxication usually goes unrecognized, and both normobaric and hyperbaric oxygen (HBO) treatments are frequently administered with delay. Current knowledge is mainly focused on acute intoxication, while Delayed Neurological Sequelae (DNS) are neglected, especially their treatment. This work details the cases of two patients presenting a few weeks after CO intoxication with severe neurological impairment and a characteristic diffused demyelination at the brain magnetic resonance imaging, posing the diagnosis of DNS. After prolonged treatment with hyperbaric oxygen, combined with intravenous corticosteroids and rehabilitation, the clinical and radiological features of DNS disappeared, and the patients’ neurological status returned to normal. Such rare cases should reinforce a thorough clinical follow-up for CO intoxication victims and promote high-quality studies.

Suggested Citation

  • Luca Martani & Andrea Giovanniello & Gerardo Bosco & Luca Cantadori & Francesca Calissi & Dany Furfaro & Massimo Pedrazzini & Rosanna Vaschetto & Enrico Mario Camporesi & Matteo Paganini, 2022. "Delayed Neurological Sequelae Successfully Treated with Adjuvant, Prolonged Hyperbaric Oxygen Therapy: Review and Case Report," IJERPH, MDPI, vol. 19(9), pages 1-9, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:9:p:5300-:d:803162
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    References listed on IDEAS

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    1. Lidio Maffi & Matteo Paganini & Giuliano Vezzani & Antonios Soumelis & ASPATI Research Group & Enrico M Camporesi & Gerardo Bosco, 2020. "Hyperbaric Oxygen Treatment for Carbon Monoxide Poisoning in Italy: Retrospective Validation of a Data Collection Tool for the Italian Registry of Carbon Monoxide Poisonings (IRCOP)," IJERPH, MDPI, vol. 17(2), pages 1-7, January.
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