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Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Author

Listed:
  • Veruscka Leso

    (Department of Public Health, Section of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
    These authors contributed equally to this work.)

  • Cristina Sottani

    (Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Via Salvatore Maugeri, 10, 27100 Pavia, Italy
    These authors contributed equally to this work.)

  • Carolina Santocono

    (Department of Public Health, Section of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy)

  • Francesco Russo

    (Department of Public Health, Section of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy)

  • Elena Grignani

    (Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Via Salvatore Maugeri, 10, 27100 Pavia, Italy
    These authors contributed equally to this work.)

  • Ivo Iavicoli

    (Department of Public Health, Section of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
    These authors contributed equally to this work.)

Abstract

The high toxicity of antineoplastic drugs (ADs) makes them dangerous not only for patients, but also for exposed workers. Therefore, the aim of this review was to provide an updated overview of the biological monitoring of occupational AD exposure in order to extrapolate information useful to improve risk assessment and management strategies in workplaces. Several studies demonstrated that remarkable portions of healthcare workers may have traces of these substances or their metabolites in biological fluids, although with some conflicting results. Nurses, directly engaged in AD handling, were the occupational category at higher risk of contamination, although, in some cases, personnel not involved in AD-related tasks also showed quantifiable internal doses. Overall, further research carried out on greater sample sizes appears necessary to gain deeper insight into the variability retrieved in the reported results. This may be important to understand the impact of the extent of ADs use, different handling, procedures, and cleaning practices, spill occurrence, training of the workforce, as well as the adoption of adequate collective and personal protective equipment in affecting the occupational exposure levels. This may support the achievement of the greatest clinical efficiency of such therapies while assuring the health and safety of involved workers.

Suggested Citation

  • Veruscka Leso & Cristina Sottani & Carolina Santocono & Francesco Russo & Elena Grignani & Ivo Iavicoli, 2022. "Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data," IJERPH, MDPI, vol. 19(6), pages 1-25, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3737-:d:776148
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    References listed on IDEAS

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    1. Jasminka Mrdjanović & Slavica Šolajić & Branislava Srđenović-Čonić & Višnja Bogdanović & Karaba-Jakovljević Dea & Nebojša Kladar & Vladimir Jurišić, 2021. "The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radia," IJERPH, MDPI, vol. 18(16), pages 1-15, August.
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    Cited by:

    1. Sophie Ndaw & Aurélie Remy, 2023. "Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination," IJERPH, MDPI, vol. 20(6), pages 1-12, March.

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