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The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress

Author

Listed:
  • Monika Fraczek

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Angelika Lewandowska

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Marta Budzinska

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Marzena Kamieniczna

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Lukasz Wojnar

    (Clinic of Urology and Oncological Urology, Poznan University of Medical Sciences, 61-285 Poznan, Poland)

  • Kamil Gill

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Malgorzata Piasecka

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Michal Kups

    (Department and Clinic Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
    The Fertility Partnership Vitrolive in Szczecin, 70-483 Szczecin, Poland)

  • Anna Havrylyuk

    (Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine)

  • Valentina Chopyak

    (Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine)

  • Jozef Nakonechnyy

    (Department of Urology, Danylo Halytskyy Lviv National Medical University, 79010 Lviv, Ukraine)

  • Andrij Nakonechnyy

    (Department of Paediatric Surgery, Danylo Halytskyy Lviv National Medical University, 79059 Lviv, Ukraine)

  • Maciej Kurpisz

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

Abstract

Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in the proportion of sperm with DNA fragmentation was observed in all the studied subgroups compared to the fertile men. In turn, the groups subjected to heat stress as professional drivers or infertile men with varicocele presented greater disturbances in the oxidative stress scavenging system than men not exposed to genital heat stress. Based on the comparative analysis of the studied parameters, we can conclude that alterations in the seminal oxidative stress scavenging system are directly engaged in the pathogenesis of ejaculated sperm DNA damage regardless of the intensity of the impact of thermal insult. To the best of our knowledge, this study, for the first time, revealed the co-existence of oxidative stress and sperm DNA damage in the semen of professional drivers.

Suggested Citation

  • Monika Fraczek & Angelika Lewandowska & Marta Budzinska & Marzena Kamieniczna & Lukasz Wojnar & Kamil Gill & Malgorzata Piasecka & Michal Kups & Anna Havrylyuk & Valentina Chopyak & Jozef Nakonechnyy , 2022. "The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress," IJERPH, MDPI, vol. 19(5), pages 1-13, February.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2713-:d:758958
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    References listed on IDEAS

    as
    1. Kamil Gill & Michal Kups & Patryk Harasny & Tomasz Machalowski & Marta Grabowska & Mariusz Lukaszuk & Marcin Matuszewski & Ewa Duchnik & Monika Fraczek & Maciej Kurpisz & Malgorzata Piasecka, 2021. "The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen," IJERPH, MDPI, vol. 18(11), pages 1-16, June.
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