IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i5p2510-d755415.html
   My bibliography  Save this article

Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data

Author

Listed:
  • Marica Iommi

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy)

  • Martina Bonifazi

    (Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60126 Ancona, Italy)

  • Andrea Faragalli

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy)

  • Lara Letizia Latini

    (Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60126 Ancona, Italy)

  • Federico Mei

    (Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60126 Ancona, Italy)

  • Liana Spazzafumo

    (Regional Health Agency of Marche, 60125 Ancona, Italy)

  • Edlira Skrami

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    National Centre for Healthcare Research and Pharmacoepidemiology, 20126 Milano, Italy)

  • Luigi Ferrante

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy)

  • Flavia Carle

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    National Centre for Healthcare Research and Pharmacoepidemiology, 20126 Milano, Italy)

  • Rosaria Gesuita

    (Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
    National Centre for Healthcare Research and Pharmacoepidemiology, 20126 Milano, Italy)

Abstract

The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.

Suggested Citation

  • Marica Iommi & Martina Bonifazi & Andrea Faragalli & Lara Letizia Latini & Federico Mei & Liana Spazzafumo & Edlira Skrami & Luigi Ferrante & Flavia Carle & Rosaria Gesuita, 2022. "Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data," IJERPH, MDPI, vol. 19(5), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2510-:d:755415
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/5/2510/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/5/2510/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marica Iommi & Andrea Faragalli & Martina Bonifazi & Federico Mei & Lara Letizia Latini & Marco Pompili & Flavia Carle & Rosaria Gesuita, 2022. "Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases," IJERPH, MDPI, vol. 19(24), pages 1-10, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2510-:d:755415. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.