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A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer

Author

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  • Sofie Bünemann Dalsgaard

    (Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark
    Danish Ramazzini Centre, Department of Occupational and Environmental Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark
    Danish Ramazzini Centre, Department of Occupational Medicine, University Research Clinic, Goedstrup Hospital, 7400 Herning, Denmark)

  • Else Toft Würtz

    (Danish Ramazzini Centre, Department of Occupational and Environmental Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark
    Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark)

  • Johnni Hansen

    (Danish Cancer Society Research Center, 2100 Copenhagen, Denmark)

  • Oluf Dimitri Røe

    (Department of Oncology, Aalborg University Hospital, 9000 Aalborg, Denmark
    Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    Department of Oncology, Levanger Hospital, Nord-Trøndelag Hospital Trust, 7600 Levanger, Norway)

  • Øyvind Omland

    (Danish Ramazzini Centre, Department of Occupational and Environmental Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark)

Abstract

Objectives: To examine the risk of cancer in former school children exposed to environmental asbestos in childhood with a focus on female cancers, including breast cancer. Methods: We retrieved a cohort of females ( n = 6024) attending four schools located in the neighborhood of a large asbestos cement plant in Denmark. A reference cohort was frequency-matched 1:9 ( n = 54,200) in sex and five-year age intervals. Using Danish registries, we linked information on historical employments, relatives’ employments, cancer, and vital status. We calculated standardized incidence rates (SIRs) for all and specific cancers, comparing these rates with the reference cohort. Hazard ratios were calculated for selected cancers adjusted for occupational and familial asbestos exposure. Results: For cancer of the corpus uteri (SIR 1.29, 95% CI 1.01–1.66) and malignant mesothelioma (SIR 7.26, 95% CI 3.26–16.15), we observed significantly increased incidences. Occupationally, asbestos exposure had a significantly increased hazard ratio for cancer in the cervix, however, a significantly lower risk of ovarian cancer. The overall cancer incidence was similar to that of the reference cohort (SIR 1.02, 95% CI 0.96–1.07). The risk of cancer of the lung was increased for those exposed to occupational asbestos, those with family members occupationally exposed to asbestos and for tobacco smokers. Conclusions: In our study, environmental asbestos exposure in childhood is associated with an increased risk of cancer of the corpus uteri and malignant mesothelioma in women.

Suggested Citation

  • Sofie Bünemann Dalsgaard & Else Toft Würtz & Johnni Hansen & Oluf Dimitri Røe & Øyvind Omland, 2022. "A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer," IJERPH, MDPI, vol. 19(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:2086-:d:748226
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    References listed on IDEAS

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    1. Emily Goswami & Valerie Craven & David L. Dahlstrom & Dominik Alexander & Fionna Mowat, 2013. "Domestic Asbestos Exposure: A Review of Epidemiologic and Exposure Data," IJERPH, MDPI, vol. 10(11), pages 1-42, October.
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    Cited by:

    1. Kathleen Mahoney & Tim Driscoll & Julia Collins & Justine Ross, 2023. "The Past, Present and Future of Asbestos-Related Diseases in Australia: What Are the Data Telling Us?," Sustainability, MDPI, vol. 15(11), pages 1-12, May.
    2. Lucia Fazzo & Giada Minelli & Marco De Santis & Emiliano Ceccarelli & Ivano Iavarone & Amerigo Zona, 2023. "The Epidemiological Surveillance of Mesothelioma Mortality in Italy as a Tool for the Prevention of Asbestos Exposure," IJERPH, MDPI, vol. 20(11), pages 1-16, May.

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