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Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification

Author

Listed:
  • Cheng-Hsien Huang

    (Department of Family Medicine, Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Tung-Jung Huang

    (Department of Pulmonary Disease and Critical Care, Chang Gung Memorial Hospital, Yunlin 638, Taiwan
    Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 613, Taiwan)

  • Yu-Chih Lin

    (Department of Family Medicine, Chang Gung Memorial Hospital, Yunlin 638, Taiwan)

  • Chia-Ni Lin

    (Department of Laboratory Medicine, Chang-Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan
    Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan)

  • Mei-Yen Chen

    (Department of Nursing, Chang Gung University of Science and Technology, Chiayi 613, Taiwan
    School of Nursing, Chang Gung University, Taoyuan 333, Taiwan
    Research Fellow, Department of Cardiology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

Abstract

Background: The association between the biomarkers of environmental exposure, oxidative stress, and health-related behaviors in community residents living in an endemic viral hepatitis area and near petrochemical industrial complexes remains unclear. From a health promotion perspective, healthcare providers must know what to do for residents concerned about their health and living environment, especially for individual-level and modifiable risk factors. Therefore, we aimed to explore the factors associated with urinary 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA). Methods: A community-based, cross-sectional study was conducted between July 2018 and February 2019 in western coastal Yunlin County, Taiwan. All participants lived within a 10 km radius of a large petrochemical complex and did not work in the factory. This study was conducted with the local hospital through annual community health screening. Biological samples were collected and biomarkers determined and quantified in the central laboratory of the collaborating hospital. Results: A total of 6335 adult residents completed the study. The mean age was 47.7 (SD = 16) years. Out of the total population, 56.4% were female, 30.1% had metabolic syndrome (MetS), and 16.8% and 14.3% had hepatitis B virus antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) positivity, respectively. The median 1-OHP and MDA level was 0.11 and 0.9 μg/g creatinine with an interquartile range of 0.07–0.18, and 0.4–1.5, respectively. The MDA levels correlated with specific diseases. The multivariable ordinal logistic regression model revealed that female sex, smoking, betel nut use, HBsAg, and anti-HCV positivity were associated with higher 1-OHP levels. In men, MetS was associated with higher 1-OHP levels and regular exercise with lower 1-OHP levels. High MDA levels were associated with smoking, betel nut users, HBsAg, and anti-HCV positivity. Conclusions: The findings highlight the importance of initiating individualized health promotion programs for residents near petrochemical factories, especially for adults with substance-use and cardiometabolic risk factors. Furthermore, it is crucial to provide further treatment to patients with viral hepatitis.

Suggested Citation

  • Cheng-Hsien Huang & Tung-Jung Huang & Yu-Chih Lin & Chia-Ni Lin & Mei-Yen Chen, 2022. "Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1362-:d:734328
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    References listed on IDEAS

    as
    1. Pin-Sheng Wu & Te-Sheng Chang & Sheng-Nan Lu & Hsiang-Jou Su & Shu-Zhi Chang & Chia-Wen Hsu & Mei-Yen Chen, 2019. "An Investigation of the Side Effects, Patient Feedback, and Physiological Changes Associated with Direct-Acting Antiviral Therapy for Hepatitis C," IJERPH, MDPI, vol. 16(24), pages 1-8, December.
    2. Mei-Yen Chen, 2021. "The Negative Impact of Parental Smoking on Adolescents’ Health-Promoting Behaviors: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(5), pages 1-8, March.
    3. Wen-Wen Chang & Hathaichon Boonhat & Ro-Ting Lin, 2020. "Incidence of Respiratory Symptoms for Residents Living Near a Petrochemical Industrial Complex: A Meta-Analysis," IJERPH, MDPI, vol. 17(7), pages 1-16, April.
    4. Yan S. Ding & Jennye Ward & David Hammond & Clifford H. Watson, 2014. "Mouth-Level Intake of Benzo[a]pyrene from Reduced Nicotine Cigarettes," IJERPH, MDPI, vol. 11(11), pages 1-17, November.
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