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The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients

Author

Listed:
  • Kiduk Kim

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Kyoonho Kang

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Hyewon Sheol

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Jihae Shin

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Youngseo Sim

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Taehoon Yang

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Jeongwon Hwang

    (Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

  • Ju-Mi Lee

    (Department of Preventive Medicine, Eulji College of Medicine, Eulji University, Daejeon 34824, Korea)

Abstract

Non-alcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) levels are risk factors for developing cardiovascular disease (CVD). Additionally, previous studies have suggested that high SUA levels increase the risk of having NAFLD. However, no study has investigated the relationship between SUA and CVD risk in NAFLD. This study analyzed the relationship between SUA and CVD in NAFLD. Data for this study used the 2016–2018 Korean National Health and Nutrition Examination Survey, which represents the Korean population. A total of 11,160 NAFLD patients were included. Participants with hepatic steatosis index ≥ 30 were considered to have NAFLD. Ten-year CVD risk was estimated using an integer-based Framingham risk score. Estimated 10-year CVD risk ≥ 20% was considered high risk. Multiple logistic regression was conducted to calculate the odds ratios (ORs) associated with SUA level and CVD risk. High CVD risk OR increases by 1.31 (95% CI 1.26–1.37) times per 1 mg/dL of SUA. After adjustment, SUA still had an increased risk (OR 1.44; 95% CI 1.38–1.51) of CVD. Compared with the lowest SUA quartile group, the highest quartile group showed a significantly higher risk of having CVD before (OR 2.76; 95% CI 2.34–3.25) and after (OR 4.01; 95% CI 3.37–4.78) adjustment. SUA is independently associated with CVS risk in NAFLD.

Suggested Citation

  • Kiduk Kim & Kyoonho Kang & Hyewon Sheol & Jihae Shin & Youngseo Sim & Taehoon Yang & Jeongwon Hwang & Ju-Mi Lee, 2022. "The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients," IJERPH, MDPI, vol. 19(3), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1042-:d:727344
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    Cited by:

    1. Domenico Di Raimondo & Gaia Musiari & Giuliana Rizzo & Edoardo Pirera & Salvatore Santo Signorelli, 2022. "New Insights in Prevention and Treatment of Cardiovascular Disease," IJERPH, MDPI, vol. 19(4), pages 1-7, February.

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