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S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent

Author

Listed:
  • Laura Abella

    (Hospital Universitari Dexeus, 08028 Barcelona, Spain)

  • Ebe D’Adamo

    (Neonatal Intensive Care Unit, G. d’Annunzio University, 65100 Chieti, Italy)

  • Mariachiara Strozzi

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Joan Sanchez-de-Toledo

    (Fetal Medicine Research Center, Hospital Sant Joan de Deus, University of Barcelona, 08950 Barcelona, Spain)

  • Miriam Perez-Cruz

    (Fetal Medicine Research Center, Hospital Sant Joan de Deus, University of Barcelona, 08950 Barcelona, Spain)

  • Olga Gómez

    (Fetal Medicine Research Center, Hospital Sant Joan de Deus, University of Barcelona, 08950 Barcelona, Spain)

  • Ernesto Abella

    (Hospital Dr. Max Peralta Jimènez, Cartago 30101, Costa Rica)

  • Maurizio Cassinari

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Roberto Guaschino

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Laura Mazzucco

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Antonio Maconi

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Stefania Testa

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Cristian Zanelli

    (Neonatal Intensive Care Unit, ASO SS Antonio, Biagio, C. Arrigo, 16100 Alessandria, Italy)

  • Marika Perrotta

    (Neonatal Intensive Care Unit, G. d’Annunzio University, 65100 Chieti, Italy)

  • Patacchiola Roberta

    (Department of Pediatrics, G. d’Annunzio University, 65100 Chieti, Italy)

  • Neri Costanza Renata

    (Department of Pediatrics, G. d’Annunzio University, 65100 Chieti, Italy)

  • Giorgia Gasparroni

    (Neonatal Intensive Care Unit, G. d’Annunzio University, 65100 Chieti, Italy)

  • Ester Vitacolonna

    (Department of Medicine and Aging, School of Medicine and Health Sciences, G. d’Annunzio University, 65100 Chieti, Italy)

  • Francesco Chiarelli

    (Department of Pediatrics, G. d’Annunzio University, 65100 Chieti, Italy)

  • Diego Gazzolo

    (Neonatal Intensive Care Unit, G. d’Annunzio University, 65100 Chieti, Italy)

Abstract

Gestational Diabetes Mellitus (GDM) is one of the main causes of perinatal mortality/morbidity. Today, a parameter offering useful information on fetal central nervous system (CNS) development/damage is eagerly awaited. We investigated the role of brain-protein S100B in the maternal blood of GDM pregnancies by means of a prospective case–control study in 646 pregnancies (GDM: n = 106; controls: n = 530). Maternal blood samples for S100B measurement were collected at four monitoring time-points from 24 weeks of gestation to term. Data was corrected for gender and delivery mode and correlated with gestational age and weight at birth. Results showed higher ( p < 0.05) S100B from 24 to 32 weeks and at term in GDM fetuses than controls. Higher ( p < 0.05) S100B was observed in GDM male new-borns than in females from 24 to 32 weeks and at term, in GDM cases delivering vaginally than by caesarean section. Finally, S100B positively correlated with gestational age and weight at birth (R = 0.27; R = 0.37, respectively; p < 0.01). The present findings show the usefulness of S100B in CNS to monitor high-risk pregnancies during perinatal standard-of-care procedures. The results suggest that further investigations into its potential role as an early marker of CNS growth/damage in GDM population are needed.

Suggested Citation

  • Laura Abella & Ebe D’Adamo & Mariachiara Strozzi & Joan Sanchez-de-Toledo & Miriam Perez-Cruz & Olga Gómez & Ernesto Abella & Maurizio Cassinari & Roberto Guaschino & Laura Mazzucco & Antonio Maconi &, 2022. "S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent," IJERPH, MDPI, vol. 19(3), pages 1-10, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1028-:d:727083
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    Cited by:

    1. Syed Mithun Ali & Andrea Appolloni & Fausto Cavallaro & Idiano D’Adamo & Assunta Di Vaio & Francesco Ferella & Massimo Gastaldi & Muhammad Ikram & Nallapaneni Manoj Kumar & Michael Alan Martin & Abdul, 2023. "Development Goals towards Sustainability," Sustainability, MDPI, vol. 15(12), pages 1-11, June.

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