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Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in Touba, Senegal

Author

Listed:
  • Idrissa Dieng

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Cheikh Fall

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Mamadou Aliou Barry

    (Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Aboubacry Gaye

    (Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Ndongo Dia

    (Respiratory Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Marie Henriette Dior Ndione

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Amary Fall

    (Respiratory Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Mamadou Diop

    (Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Fatoumata Diene Sarr

    (Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Oumar Ndiaye

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Mamadou Dieng

    (Ministry of Health, Dakar 16504, Senegal)

  • Boly Diop

    (Ministry of Health, Dakar 16504, Senegal)

  • Cheikh Tidiane Diagne

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Mamadou Ndiaye

    (Ministry of Health, Dakar 16504, Senegal)

  • Gamou Fall

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Mbacké Sylla

    (Ministry of Health, Dakar 16504, Senegal)

  • Ousmane Faye

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Cheikh Loucoubar

    (Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Oumar Faye

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

  • Amadou Alpha Sall

    (Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal)

Abstract

Dengue virus (DENV) was detected in Senegal in 1979 for the first time. Since 2017, unprecedented frequent outbreaks of DENV were noticed yearly. In this context, epidemiological and molecular evolution data are paramount to decipher the virus diffusion route. In the current study, we focused on a dengue outbreak which occurred in Senegal in 2018 in the context of a large religious gathering with 263 confirmed DENV cases out of 832 collected samples, including 25 life-threatening cases and 2 deaths. It was characterized by a co-circulation of dengue serotypes 1 and 3. Phylogenetic analysis based on the E gene revealed that the main detected serotype in Touba was DENV-3 and belonged to Genotype III. Bayesian phylogeographic analysis was performed and suggested one viral introduction around 2017.07 (95% HPD = 2016.61–2017.57) followed by cryptic circulation before the identification of the first case on 1 October 2018. DENV-3 strains are phylogenetically related, with strong phylogenetic links between strains retrieved from Burkina Faso and other West African countries. These phylogenetic data substantiate epidemiological data of the origin of DENV-3 and its spread between African countries and subsequent diffusion after religious mass events. The study also highlighted the usefulness of a mobile laboratory during the outbreak response, allowing rapid diagnosis and resulting in improved patient management.

Suggested Citation

  • Idrissa Dieng & Cheikh Fall & Mamadou Aliou Barry & Aboubacry Gaye & Ndongo Dia & Marie Henriette Dior Ndione & Amary Fall & Mamadou Diop & Fatoumata Diene Sarr & Oumar Ndiaye & Mamadou Dieng & Boly D, 2022. "Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in Touba, Senegal," IJERPH, MDPI, vol. 19(24), pages 1-13, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:24:p:16912-:d:1005399
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    References listed on IDEAS

    as
    1. Kuan-Meng Soo & Bahariah Khalid & Siew-Mooi Ching & Hui-Yee Chee, 2016. "Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-16, May.
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