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Disease Activity Is Associated with Obesity in Newly Diagnosed Pediatric Patients with Ulcerative Colitis

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Listed:
  • Orsolya Kadenczki

    (Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary)

  • Antal Dezsofi

    (1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary)

  • Aron Cseh

    (1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary)

  • Daniel Szucs

    (Department of Pediatrics, University of Szeged, 6725 Szeged, Hungary)

  • Noemi Vass

    (Department of Pediatrics, University of Szeged, 6725 Szeged, Hungary)

  • Eva Nemes

    (Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary)

  • Andras Tarnok

    (Department of Pediatrics, Medical School, University of Pécs, 7623 Pécs, Hungary)

  • Erzsebet Szakos

    (Borsod Abaúj Zemplén County University Teaching Hospital, University of Miskolc, 3526 Miskolc, Hungary)

  • Ildiko Guthy

    (Szabolcs-Szatmár-Bereg County Hospitals, University Teaching Hospital, 4400 Nyíregyháza, Hungary)

  • Marta Kovacs

    (Petz Aladar Teaching Hospital, 9024 Győr, Hungary)

  • Anna Karoliny

    (Heim Pal National Pediatric Institute, 1089 Budapest, Hungary)

  • Judit Czelecz

    (Bethesda Children’s Hospital, 1146 Budapest, Hungary)

  • Csongor Kiss

    (Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
    These authors contributed equally to this work.)

  • Katalin Eszter Müller

    (Heim Pal National Pediatric Institute, 1089 Budapest, Hungary
    Institute of Translation Medicine, Medical School, University of Pécs, 7623 Pécs, Hungary
    These authors contributed equally to this work.)

Abstract

Malnutrition and inflammatory bowel disease (IBD) are interrelated conditions. Our aim was to assess the prevalence of malnutrition, to compare anthropometric parameters in the evaluation of nutritional status in pediatric IBD, and to investigate the association between anthropometric parameters and disease activity indices (AI). Pediatric patients with newly diagnosed IBD recorded between 2010 and 2016 in the Hungarian Pediatric IBD Registry were included in this cross-sectional study. Body weight, body mass index (BMI), weight-for-height, and ideal body weight percent (IBW%) were analyzed. Pearson linear and non-linear correlations and polynomial regression analyses were performed to assess correlation between nutritional status and AI. p -values < 0.05 were considered significant. Anthropometric data of 1027 children with IBD (Crohn’s disease (CD): 699; ulcerative colitis (UC): 328; mean age 13.7 years) were analyzed. IBW% identified more obese patients than BMI both in CD (7.02% vs. 2.28%) and UC (12.17% vs. 5.48%). Significant negative correlation was found among anthropometric parameters and AI in CD. In contrast, polynomial regression analysis revealed a U-shaped correlation curve between IBW% and AI in UC. Our findings show that obesity has a bimodal association with disease activity in pediatric UC. Furthermore, IBW% was more useful to identify obese pediatric patients with IBD.

Suggested Citation

  • Orsolya Kadenczki & Antal Dezsofi & Aron Cseh & Daniel Szucs & Noemi Vass & Eva Nemes & Andras Tarnok & Erzsebet Szakos & Ildiko Guthy & Marta Kovacs & Anna Karoliny & Judit Czelecz & Csongor Kiss & K, 2022. "Disease Activity Is Associated with Obesity in Newly Diagnosed Pediatric Patients with Ulcerative Colitis," IJERPH, MDPI, vol. 19(23), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:16091-:d:990575
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    References listed on IDEAS

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    1. Orsolya Kadenczki & Attila Csaba Nagy & Csongor Kiss, 2021. "Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary," IJERPH, MDPI, vol. 18(4), pages 1-11, February.
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