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Side-Effects following Oxford/AstraZeneca COVID-19 Vaccine in Tororo District, Eastern Uganda: A Cross-Sectional Study

Author

Listed:
  • Jagire Onyango

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • David Mukunya

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda
    Department of Research, Nikao Medical Center, Kampala P.O. Box 10005, Uganda)

  • Agnes Napyo

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • Ritah Nantale

    (Department of Nursing, Busitema University, Mbale P.O. Box 236, Uganda)

  • Brian T. Makoko

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • Joseph K. B. Matovu

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda
    Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala P.O. Box 7072, Uganda)

  • Benon Wanume

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • David Okia

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • Francis Okello

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

  • Sam Okware

    (Department of Research, Uganda National Health Research Organizations, Kampala P.O. Box 465, Uganda)

  • Peter Olupot-Olupot

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda
    Department of Research, Mbale Clinical Research Institute, Mbale P.O. Box 1966, Uganda)

  • Yovani Lubaale

    (Department of Community and Public Health, Busitema University, Mbale P.O. Box 236, Uganda)

Abstract

Effective, safe and proven vaccines would be the most effective strategy against the COVID-19 pandemic but have faced rollout challenges partly due to fear of potential side-effects. We assessed the prevalence, profiles, and predictors of Oxford/AstraZeneca vaccine side-effects in Tororo district of Eastern Uganda. We conducted telephone interviews with 2204 participants between October 2021 and January 2022. Multivariable logistic regression was conducted to assess factors associated with Oxford/AstraZeneca vaccine side-effects using Stata version 15.0. A total of 603/2204 (27.4%) of the participants experienced one or more side-effects (local, systemic, allergic, and other side-effects). Of these, 253/603 (42.0%) experienced local side-effects, 449/603 (74.5%) experienced systemic side-effects, 11/603 (1.8%) experienced allergic reactions, and 166/603 (27.5%) experienced other side-effects. Ten participants declined to receive the second dose because of side-effects they had experienced after the first dose. Previous infection with COVID-19 (adjusted odds ratio (AOR): 4.3, 95% confidence interval (95% CI): 2.7–7.0), being female (AOR: 1.3, 95% CI: 1.1–1.6) and being a security officer (AOR: 0.4, 95% CI: 0.2–0.6) were associated with side-effects to the Oxford/AstraZeneca vaccine. We recommend campaigns to disseminate correct information about potential side-effects of the Oxford/AstraZeneca vaccine and strengthen surveillance for adverse events following vaccination.

Suggested Citation

  • Jagire Onyango & David Mukunya & Agnes Napyo & Ritah Nantale & Brian T. Makoko & Joseph K. B. Matovu & Benon Wanume & David Okia & Francis Okello & Sam Okware & Peter Olupot-Olupot & Yovani Lubaale, 2022. "Side-Effects following Oxford/AstraZeneca COVID-19 Vaccine in Tororo District, Eastern Uganda: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(22), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:15303-:d:977842
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