IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i22p15219-d976520.html
   My bibliography  Save this article

Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis

Author

Listed:
  • Wojciech Konarski

    (Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland)

  • Tomasz Poboży

    (Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland)

  • Andrzej Kotela

    (Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland)

  • Andrzej Śliwczyński

    (Social Medicine Institute, (Department of Social and Preventive Medicine), Medical University of Lodz, 90-419 Lodz, Poland)

  • Ireneusz Kotela

    (Department of Orthopedic Surgery and Traumatology, Central Research Hospital of Ministry of Interior, Wołoska 137, 02-507 Warsaw, Poland)

  • Martyna Hordowicz

    (General Psychiatry Unit III, Dr. Barbara Borzym’s Independent Public Regional Psychiatric Health Care Center, 26-600 Radom, Poland)

  • Jan Krakowiak

    (Social Medicine Institute, (Department of Social and Preventive Medicine), Medical University of Lodz, 90-419 Lodz, Poland)

Abstract

Avascular osteonecrosis (AVN) is caused by the disrupted blood supply to the bone. Most AVN cases occur in the femoral head, but other sites might be affected as well, including the jaw or distal bones of the extremities. Previous studies suggested that diabetes could increase the risk of AVN of the jaw, but the relationship between diabetes and AVN in other bone sites is unclear. This systematic review and meta-analysis aimed to summarize the evidence from studies that had reported on the occurrence of AVN in sites other than the jaw, depending on the diagnosis of diabetes. Overall, we included 6 observational studies carried out in different populations: primary or secondary AVN of the femoral head, Takayasu arteritis, general population, kidney transplant recipients, systemic lupus erythematosus, and primary brain tumors. A random-effects meta-analysis showed that the risk of AVN in sites other than the jaw was non-significantly increased in patients with diabetes (odds ratio: 1.90, 95% confidence interval: 0.93–3.91). The pooled estimate increased and was significant after the exclusion of one study (2.46, 1.14–5.32). There was a significant heterogeneity (I 2 = 65%, tau 2 = 0.48, p = 0.01; prediction interval, 0.21–16.84). There was no significant publication bias ( p = 0.432). In conclusion, diabetes could increase the risk of AVN in sites other than the jaw, but the available evidence is limited. There is a need for large, well-designed, population-based studies.

Suggested Citation

  • Wojciech Konarski & Tomasz Poboży & Andrzej Kotela & Andrzej Śliwczyński & Ireneusz Kotela & Martyna Hordowicz & Jan Krakowiak, 2022. "Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(22), pages 1-9, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:15219-:d:976520
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/22/15219/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/22/15219/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Wojciech Konarski & Tomasz Poboży & Andrzej Kotela & Andrzej Śliwczyński & Ireneusz Kotela & Martyna Hordowicz & Jan Krakowiak, 2022. "The Risk of Avascular Necrosis Following the Stabilization of Femoral Neck Fractures: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(16), pages 1-16, August.
    2. Wojciech Konarski & Tomasz Poboży & Martyna Hordowicz & Andrzej Śliwczyński & Ireneusz Kotela & Jan Krakowiak & Andrzej Kotela, 2022. "Bone Infarcts and Tumorigenesis—Is There a Connection? A Mini-Mapping Review," IJERPH, MDPI, vol. 19(15), pages 1-15, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:15219-:d:976520. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.