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Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan

Author

Listed:
  • Sholpan Koigeldinova

    (Department of Internal Diseases, Karaganda Medical University, 40 Gogol street, Karaganda 100008, Kazakhstan)

  • Alexey Alexeyev

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

  • Zhengisbek Zharylkassyn

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

  • Yertay Otarov

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

  • Bauyrzhan Omarkulov

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

  • Magzhan Tilemissov

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

  • Chingiz Ismailov

    (Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan)

Abstract

The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only enterprise dealing with the extraction and beneficiation of chrysotile ores in Kazakhstan. Indicants of cell immunity were detected by flow cytometry; IgA, IgM, and IgG were detected by a multiplex immunological assay. It was found that, among workers impacted by chrysotile asbestos for more than 15 years, compared with individuals who were not impacted by asbestos dust, the level of CD3+ T-cells was decreased ( t = −8.76, p < 0.001), as well as the number of CD4+ T-cells (U = 1246.0, p < 0.001). Moreover, CD8+ T-cells increased ( t = 5.308, p = 0.001), and neutrophil phagocytic activity also increased, by 1.2 times (U = 305.5, p < 0.001). It was found that working under the condition of professional contact with chrysotile asbestos dust modifies the indicants of humoral immunity, IgA, IgM, and IgG, to a lesser extent than those of cellular immunity.

Suggested Citation

  • Sholpan Koigeldinova & Alexey Alexeyev & Zhengisbek Zharylkassyn & Yertay Otarov & Bauyrzhan Omarkulov & Magzhan Tilemissov & Chingiz Ismailov, 2022. "Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan," IJERPH, MDPI, vol. 19(21), pages 1-8, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14603-:d:965465
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    References listed on IDEAS

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    1. Emma K. Austin & Carole James & John Tessier, 2021. "Early Detection Methods for Silicosis in Australia and Internationally: A Review of the Literature," IJERPH, MDPI, vol. 18(15), pages 1-24, July.
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