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Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession—A Systematic Review

Author

Listed:
  • Vini Mehta

    (Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune 411018, India)

  • Gerta Kaçani

    (Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania)

  • Mohammed M. Al Moaleem

    (Department of Prosthetic Dental Science, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia
    Faculty of Dentistry, University of Ibn Al-Nafis for Medical Sciences, Sana’a 4337, Yemen)

  • Anwar Abdulkarim Almohammadi

    (College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia)

  • Malak Mohammed Alwafi

    (College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia)

  • Abduljabbar Khalil Mulla

    (College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia)

  • Shahad Owaidh Alharbi

    (College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia)

  • Abdullah Waleed Aljayyar

    (College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia)

  • Etleva Qeli

    (Department of Conservative, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania)

  • Çeljana Toti

    (Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania)

  • Agron Meto

    (Department of Dentistry, University of Aldent, 1007 Tirana, Albania)

  • Luca Fiorillo

    (Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98100 Messina, Italy
    Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy)

Abstract

This systematic review aimed to investigate the effectiveness of hyaluronic acid (HA) on the clinical treatment outcomes of patients with gingival recession. A systematic search was performed in PubMed, Cochrane Central Register of Controlled Trials, Embase, Scopus, and Google Scholar for studies up to 15 August 2022. Two reviewers separately selected the papers for eligibility after conducting a thorough search. The study includes randomized controlled clinical trials in which participants were given HA in addition to periodontal treatment surgical procedures. The changes following the treatment protocol were evaluated for complete and mean root coverage as a primary outcome and gingival recession gain as the secondary outcome. Three articles met the eligibility criteria out of 557 titles. In periodontal surgery, HA exhibited better results in complete root coverage and mean root coverage when compared to the control group. Gingival recession reduction, clinical attachment level, and keratinized tissue gain were significantly increased compared to the control groups. However, the comparison presented in the following study might show heterogeneity among the studies and risk of bias in general. Given the scope of this analysis, results suggest that adjunctive treatment with HA gel for root coverage could be clinically beneficial.

Suggested Citation

  • Vini Mehta & Gerta Kaçani & Mohammed M. Al Moaleem & Anwar Abdulkarim Almohammadi & Malak Mohammed Alwafi & Abduljabbar Khalil Mulla & Shahad Owaidh Alharbi & Abdullah Waleed Aljayyar & Etleva Qeli & , 2022. "Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession—A Systematic Review," IJERPH, MDPI, vol. 19(21), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14330-:d:960979
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    References listed on IDEAS

    as
    1. Gabriele Cervino & Agron Meto & Luca Fiorillo & Alessandra Odorici & Aida Meto & Cesare D’Amico & Giacomo Oteri & Marco Cicciù, 2021. "Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data," IJERPH, MDPI, vol. 18(9), pages 1-15, April.
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