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Toxic Encephalopathy and Methemoglobinemia after 5-Amino-2-(trifluoromethyl)pyridine Poisoning

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  • Yiming Tao

    (Department of Intensive Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China
    Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China)

  • Longke Shi

    (School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China)

  • Jie Han

    (Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China)

  • Xiangdong Jian

    (Department of Poisoning and Occupational Diseases, Qilu Hospital of Shandong University, No. 107, Road Wenhuaxi, Jinan 250012, China)

  • Yongsheng Li

    (Department of Intensive Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China
    Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China)

Abstract

The aromatic amino compound 5-amino-2-(trifluoromethyl)pyridine acts as an intermediate in the synthesis of pharmaceutical products. However, the toxicity profile of this compound is sparse and no related poisoning events have been reported. Here, we report the case of a 35-year-old man who inhaled 5-amino-2-(trifluoromethyl)pyridine at work. After inhalation, the patient rapidly developed symptoms such as dizziness, fatigue, nausea, vomiting, chest tightness, and loss of consciousness. After admission, methemoglobinemia, hemolytic anemia, acute renal failure, and toxic encephalopathy occurred. Symptoms improved significantly after intravenous treatment with a low dose of methylene blue. This revealed that 5-amino-2-(trifluoromethyl)pyridine is toxic to the human body and can be absorbed through the respiratory tract, resulting in methemoglobinemia and toxic encephalopathy; thus, caution should be taken in industrial production.

Suggested Citation

  • Yiming Tao & Longke Shi & Jie Han & Xiangdong Jian & Yongsheng Li, 2022. "Toxic Encephalopathy and Methemoglobinemia after 5-Amino-2-(trifluoromethyl)pyridine Poisoning," IJERPH, MDPI, vol. 19(21), pages 1-6, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14031-:d:955781
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    References listed on IDEAS

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    1. Giulia Cannata & Luciana Abate & Chiara Scarabello & Monica Rubini & Alessandra Giacometti & Nicola Principi & Susanna Esposito & Icilio Dodi, 2020. "The Dose Makes the Poison: A Case Report of Acquired Methemoglobinemia," IJERPH, MDPI, vol. 17(6), pages 1-5, March.
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