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Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer

Author

Listed:
  • Virginia Soria-Utrilla

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain)

  • Francisco José Sánchez-Torralvo

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain
    Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain
    Departamento de Medicina y Dermatología, Facultad de Medicina, University of Malaga, 29010 Malaga, Spain)

  • Iván González-Poveda

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • Santiago Mera-Velasco

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • Nuria Porras

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain)

  • José Antonio Toval-Mata

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • María García-Olivares

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain)

  • Manuel Ruiz-López

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • Montserrat Gonzalo-Marín

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain
    Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain)

  • Joaquín Carrasco-Campos

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • María José Tapia

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain
    Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain)

  • Julio Santoyo-Santoyo

    (Unidad de Gestión Clínica de Cirugía General y Digestiva, Hospital Regional Universitario de Málaga, 29010 Malaga, Spain)

  • Gabriel Olveira

    (Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain
    Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain
    Departamento de Medicina y Dermatología, Facultad de Medicina, University of Malaga, 29010 Malaga, Spain
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain)

Abstract

Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality.

Suggested Citation

  • Virginia Soria-Utrilla & Francisco José Sánchez-Torralvo & Iván González-Poveda & Santiago Mera-Velasco & Nuria Porras & José Antonio Toval-Mata & María García-Olivares & Manuel Ruiz-López & Montserra, 2022. "Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer," IJERPH, MDPI, vol. 19(20), pages 1-10, October.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13548-:d:947211
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    References listed on IDEAS

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    1. Yu-Ning Peng & Mei-Li Huang & Chia-Hung Kao, 2019. "Prevalence of Depression and Anxiety in Colorectal Cancer Patients: A Literature Review," IJERPH, MDPI, vol. 16(3), pages 1-12, January.
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