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The Influence of HLA Alleles on the Affective Distress Profile

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  • Mihaela Laura Vică

    (Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
    Institute of Legal Medicine, 400006 Cluj-Napoca, Romania)

  • Cristian Delcea

    (Institute of Legal Medicine, 400006 Cluj-Napoca, Romania
    Faculty of Psychology, “Tibiscus” University, 300559 Timișoara, Romania
    Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania)

  • Gabriela Alina Dumitrel

    (Faculty of Industrial Chemistry and Environmental Engineering, Polytechnic University, 300223 Timișoara, Romania)

  • Mihaela Elvira Vușcan

    (Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
    Institute of Legal Medicine, 400006 Cluj-Napoca, Romania)

  • Horea Vladi Matei

    (Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
    Institute of Legal Medicine, 400006 Cluj-Napoca, Romania)

  • Cosmin Adrian Teodoru

    (Clinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University, 550002 Sibiu, Romania)

  • Costel Vasile Siserman

    (Institute of Legal Medicine, 400006 Cluj-Napoca, Romania
    Department of Legal Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania)

Abstract

(1) Background: Affective distress can be triggered by aggressive stimuli with an unfavorable role for the individual. Some of the factors that lead to the development and evolution of a mental disorder can be genetic. The aim of this study is to determine some correlations between the human leukocyte antigen (HLA) genes and the affective distress profile (PDA). (2) Methods: A psychological assessment and testing tool for anxiety was applied to 115 people. The low-resolution HLA alleles of class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1 and HLA-DQB1) were identified by the PCR technique after DNA extraction from the blood. Depending on the PDA, the subjects were divided into two groups: a group with a low PDA and another one with a medium and high PDA. The IBM SPSS software was used to compare the frequency of HLA alleles between the two groups. (3) Results: The univariate analysis revealed a significant association of the HLA-A locus (A*01, A*30), HLA-B (B*08), and HLA-DRB1 (DRB1*11) with the low PDA group and of the HLA-A locus (A*32), HLA-B (B*52), and HLA-C (C*12) with the medium and high PDA group. (4) Conclusions: The present study highlighted potential associations between HLA alleles and anxiety disorders.

Suggested Citation

  • Mihaela Laura Vică & Cristian Delcea & Gabriela Alina Dumitrel & Mihaela Elvira Vușcan & Horea Vladi Matei & Cosmin Adrian Teodoru & Costel Vasile Siserman, 2022. "The Influence of HLA Alleles on the Affective Distress Profile," IJERPH, MDPI, vol. 19(19), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12608-:d:932087
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