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Changes in Novel Anthropometric Indices of Abdominal Obesity during Weight Loss with Selected Obesity-Associated Single-Nucleotide Polymorphisms: A Small One-Year Pilot Study

Author

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  • Katarzyna Iłowiecka

    (Department of Food and Nutrition, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland)

  • Paweł Glibowski

    (Department of Biotechnology, Microbiology and Human Nutrition, University of Life Science in Lublin, 8 Skromna Str., 20-704 Lublin, Poland)

  • Justyna Libera

    (Division of Engineering and Cereals Technology, Department of Plant Food Technology and Gastronomy, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland)

  • Wojciech Koch

    (Department of Food and Nutrition, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland)

Abstract

Whether BMI and the competing waist circumference (WC)-based anthropometric indices are associated with obesity-related single-nucleotide polymorphisms (SNPs) is as yet unknown. The current study aimed to evaluate the anthropometric indices (fat mass index, body shape index, visceral adiposity index, relative fat mass, body roundness index, and conicity index) during a weight loss intervention in 36 obese individuals. Blood biochemical parameters (total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides) and three SNPs (FTO rs9939609, TFAP2B rs987237, and PLIN1 rs894160) were assessed in 22 women and 14 men (35.58 ± 9.85 years, BMI 35.04 ± 3.80 kg/m 2 ) who completed a 12-month balanced energy-restricted diet weight loss program. Body composition was assessed via bioelectrical impedance (SECA mBCA515). At the end of the weight loss intervention, all anthropometric indices were significantly reduced ( p < 0.05). For the SNP FTO rs9939609, the higher risk allele (A) was characteristic of 88.9% of the study group, in which 10 participants (27.8%) were homozygous. We found a similar distribution of alleles in TFAP2B and PLIN1. Heterozygous genotypes in FTO rs9939609 and TFAP2B rs987237 were predisposed to significant reductions in WC-based novel anthropometric indices during weight loss. The influence of PLIN1 rs894160 polymorphisms on the changes in the analyzed indices during weight loss has not been documented in the present study.

Suggested Citation

  • Katarzyna Iłowiecka & Paweł Glibowski & Justyna Libera & Wojciech Koch, 2022. "Changes in Novel Anthropometric Indices of Abdominal Obesity during Weight Loss with Selected Obesity-Associated Single-Nucleotide Polymorphisms: A Small One-Year Pilot Study," IJERPH, MDPI, vol. 19(18), pages 1-16, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11837-:d:919260
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    References listed on IDEAS

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    1. Mbelege Rosina Nkwana & Kotsedi Daniel Monyeki & Sogolo Lucky Lebelo, 2021. "Body Roundness Index, A Body Shape Index, Conicity Index, and Their Association with Nutritional Status and Cardiovascular Risk Factors in South African Rural Young Adults," IJERPH, MDPI, vol. 18(1), pages 1-13, January.
    2. Julián F. Calderón-García & Raúl Roncero-Martín & Sergio Rico-Martín & Jorge M. De Nicolás-Jiménez & Fidel López-Espuela & Esperanza Santano-Mogena & Pilar Alfageme-García & Juan F. Sánchez Muñoz-Torr, 2021. "Effectiveness of Body Roundness Index (BRI) and a Body Shape Index (ABSI) in Predicting Hypertension: A Systematic Review and Meta-Analysis of Observational Studies," IJERPH, MDPI, vol. 18(21), pages 1-22, November.
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