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Liposomes Containing Amaranth Unsaponifiable Matter and Soybean Lunasin Suppress ROS Production in Fibroblasts and Reduced Interleukin Production in Macrophages

Author

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  • Gloria Dávila-Ortiz

    (Unidad Profesional Adolfo López Mateos, Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Campus Zacatenco, Madero, Ciudad de México 07738, Mexico)

  • Erick Damian Castañeda-Reyes

    (Unidad Profesional Adolfo López Mateos, Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Campus Zacatenco, Madero, Ciudad de México 07738, Mexico
    Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, IL 61801, USA)

  • Carlos Ignacio Juárez-Palomo

    (Unidad Profesional Adolfo López Mateos, Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Campus Zacatenco, Madero, Ciudad de México 07738, Mexico)

  • María de Jesús Perea-Flores

    (Unidad Profesional Adolfo López Mateos, Centro de Nanociencias y Micro y Nanotecnologías, Instituto Politécnico Nacional (IPN), Av. Luis Enrique Erro s/n, Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de México 07738, Mexico)

  • Ricardo Pérez-Pastén-Borja

    (Unidad Profesional Adolfo López Mateos, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Campus Zacatenco, Madero, Ciudad de México 07738, Mexico)

  • Yazmín Karina Márquez-Flores

    (Unidad Profesional Adolfo López Mateos, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Campus Zacatenco, Madero, Ciudad de México 07738, Mexico)

  • Elvira González de Mejía

    (Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, IL 61801, USA)

Abstract

Inflammation is a normal response in defense to agents that may cause damage to the human body. When inflammation becomes chronic, reactive oxygen species (ROS) are produced; which could lead to diseases such as cancer. The aim was to assess liposomes’ antioxidant and anti-inflammatory capacity loaded with amaranth unsaponifiable matter and soybean lunasin (UM + LunLip) in an in vitro model using fibroblasts and macrophages. To evaluate ROS production, fibroblasts CHON-002 ABAP were added to promote ROS production; and the cells were treated with UM + LunLip. For inflammation markers production, lipopolysaccharides (LPS)-stimulated RAW 264.7 and peritoneal macrophages were treated with empty liposomes (EmLip), liposomes loaded with unsaponifiable matter (UMLip), liposomes loaded with lunasin (LunLip), and UM + LunLip. ROS production was significantly decreased by 77% ( p < 0.05) when fibroblasts were treated with UM + LunLip at 2 mg lunasin/mL compared with the control treated with ABAP. Treatment with UMLip was the most effective in reducing tumor necrosis factor-α (71–90%) and interleukin-6 (43–55%, p < 0.001). Both liposomes containing unsaponifiable matter (UMLip and UM + LunLip) were more effective than EmLip or LunLip. In conclusion, amaranth unsaponifiable matter-loaded liposomes are effective in decreasing pro-inflammatory cytokine production.

Suggested Citation

  • Gloria Dávila-Ortiz & Erick Damian Castañeda-Reyes & Carlos Ignacio Juárez-Palomo & María de Jesús Perea-Flores & Ricardo Pérez-Pastén-Borja & Yazmín Karina Márquez-Flores & Elvira González de Mejía, 2022. "Liposomes Containing Amaranth Unsaponifiable Matter and Soybean Lunasin Suppress ROS Production in Fibroblasts and Reduced Interleukin Production in Macrophages," IJERPH, MDPI, vol. 19(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11678-:d:916691
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    References listed on IDEAS

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    1. Hyun Ju Park & Sang-Mi Jo & Seok Hee Seo & Myoungsook Lee & Yunkyoung Lee & Inhae Kang, 2020. "Anti-Inflammatory Potential of Cultured Ginseng Roots Extract in Lipopolysaccharide-Stimulated Mouse Macrophages and Adipocytes," IJERPH, MDPI, vol. 17(13), pages 1-15, June.
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