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The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility

Author

Listed:
  • Ksawery Goławski

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland)

  • Robert Soczewica

    (College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, 02-097 Warsaw, Poland)

  • Joanna Kacperczyk-Bartnik

    (2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, 00-315 Warsaw, Poland
    Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland)

  • Grzegorz Mańka

    (Angelius Provita Hospital, 40-611 Katowice, Poland)

  • Mariusz Kiecka

    (Angelius Provita Hospital, 40-611 Katowice, Poland)

  • Michał Lipa

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland
    Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland)

  • Damian Warzecha

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland)

  • Robert Spaczyński

    (Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-572 Poznan, Poland)

  • Piotr Piekarski

    (Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-572 Poznan, Poland)

  • Beata Banaszewska

    (Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-572 Poznan, Poland)

  • Artur Jakimiuk

    (Department of Reproductive Health, Insitute of Mother and Child in Warsaw, 01-211 Warsaw, Poland
    Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland)

  • Tadeusz Issat

    (Department of Reproductive Health, Insitute of Mother and Child in Warsaw, 01-211 Warsaw, Poland
    Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland)

  • Wojciech Rokita

    (Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland
    Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, 25-736 Kielce, Poland)

  • Jakub Młodawski

    (Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland
    Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, 25-736 Kielce, Poland)

  • Maria Szubert

    (Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland
    Department of Gynecology and Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland
    Department of Surgical Gynecology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland)

  • Piotr Sieroszewski

    (Department of Gynecology and Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland
    Department of Fetal Medicine and Gynecology, Medical University of Lodz, 90-419 Lodz, Poland)

  • Grzegorz Raba

    (Clinic of Obstetrics and Gynecology in Przemysl, 37-700 Przemysl, Poland
    Department of Obstetrics and Gynecology, University of Rzeszow, 35-310 Rzeszow, Poland)

  • Kamil Szczupak

    (Clinic of Obstetrics and Gynecology in Przemysl, 37-700 Przemysl, Poland
    Department of Obstetrics and Gynecology, University of Rzeszow, 35-310 Rzeszow, Poland)

  • Tomasz Kluz

    (Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland)

  • Marek Kluza

    (Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland)

  • Mirosław Wielgoś

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland)

  • Ewa Koc-Żórawska

    (2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-089 Bialystok, Poland)

  • Marcin Żórawski

    (Department of Clinical Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland)

  • Piotr Laudański

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland
    OVIklinika Infertility Center, 01-377 Warsaw, Poland)

Abstract

Cadherin 12 (CDH 12) can play a role in the pathogenesis of endometriosis. The aim of this study was to compare the levels of cadherin 12 in the peritoneal fluid between women with and without endometriosis. This was a multicenter cross-sectional study. Eighty-two patients undergoing laparoscopic procedures were enrolled in the study. Cadherin 12 concentrations were determined using the enzyme-linked immunosorbent assay. The level of statistical significance was set at p < 0.05. No differences in cadherin 12 concentrations between patients with and without endometriosis were observed ( p = 0.4). Subgroup analyses showed that CDH 12 concentrations were significantly higher in patients with infertility or primary infertility and endometriosis in comparison with patients without endometriosis and without infertility or primary infertility ( p = 0.02) and also higher in patients with stage I or II endometriosis and infertility or primary infertility than in patients without endometriosis and infertility or primary infertility ( p = 0.03, p = 0.048, respectively). In total, CDH 12 levels were significantly higher in patients diagnosed with infertility or primary infertility ( p = 0.0092, p = 0.009, respectively) than in fertile women. Cadherin 12 can possibly play a role in the pathogenesis of infertility, both in women with and without endometriosis.

Suggested Citation

  • Ksawery Goławski & Robert Soczewica & Joanna Kacperczyk-Bartnik & Grzegorz Mańka & Mariusz Kiecka & Michał Lipa & Damian Warzecha & Robert Spaczyński & Piotr Piekarski & Beata Banaszewska & Artur Jaki, 2022. "The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility," IJERPH, MDPI, vol. 19(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11586-:d:914830
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