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Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study

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  • Jelena Milosevic

    (Department of Physical Medicine and Rehabilitation, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
    Clinic of Orthopedics and Traumatology, University Cinical Center of Kragujevac, 34000 Kragujevac, Serbia)

  • Milena Jurisevic

    (Department of Clinical Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia)

  • Vesna Grbovic

    (Department of Physical Medicine and Rehabilitation, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
    Department of Physical Medicine and Rehabilitation, University Clinical Center of Kragujevac, 34000 Kragujevac, Serbia)

  • Ivan Jovanovic

    (Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia)

  • Nevena Gajovic

    (Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia)

  • Aleksandra Jurisic-Skevin

    (Department of Physical Medicine and Rehabilitation, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
    Department of Physical Medicine and Rehabilitation, University Clinical Center of Kragujevac, 34000 Kragujevac, Serbia)

Abstract

Background: Gonarthrosis and diabetes mellitus are two diseases that are increasingly being linked. The aim of this study was to quantify serum levels of Gal-3, pro- and anti-inflammatory cytokines (including their ratios and correlations), and participant’s condition (pain, stiffness, functional limitations) in gonarthrosis patients with and without diabetes mellitus. Methods: A between-subject, cross-sectional experimental design was adopted. Serum levels of TNF-α, IL-6, IL-12, IL-23, IFN-γ, IL-17, IL-10, Gal-3, and WOMAC score were measured. Results: Gonarthrosis patients with diabetes mellitus had significantly ( p < 0.05) lower levels of TNF-α, IL-6, IL-12, IL-17, IFN-γ, and Gal-3 compared to gonarthrosis patients without diabetes mellitus. On the other hand, IL-10/TNF-α, IL-10/IL-6, IL-10/IL-12, Gal-3/TNF-α, Gal-3/IL-6, and Gal-3/IL-12 ( p = 0.001) were significantly higher ( p < 0.05) in gonarthrosis with diabetes mellitus. Moderate–large correlation ( p < 0.05) was detected between the serum values of Gal-3 and pro- and anti-inflammatory cytokines, including IL-12 (r = 0.575), IL-10 (r = 0.535), TNF-α (r = 0.306), and IL-23 (r = 0.323). WOMAC index was significantly lower ( p < 0.05) in gonarthrosis patients without diabetes mellitus compared to gonarthrosis patients with diabetes mellitus. Conclusions: Correlation between Gal-3 and proinflammatory cytokines and its dominance over proinflammatory cytokines implicate the potential role of Gal-3 in preventing cartilage destruction.

Suggested Citation

  • Jelena Milosevic & Milena Jurisevic & Vesna Grbovic & Ivan Jovanovic & Nevena Gajovic & Aleksandra Jurisic-Skevin, 2022. "Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(18), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11480-:d:913033
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    1. Gaojun Cai & Xinyong Zhang & Weijin Weng & Ganwei Shi & Sheliang Xue & Bifeng Zhang, 2017. "Associations between PPARG polymorphisms and the risk of essential hypertension," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-17, July.
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