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Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis

Author

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  • Jihee Choi

    (Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

  • Jong-Yeon Kim

    (Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Department of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

  • Hae-Jeung Lee

    (Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

Abstract

Background: Perfluorooctanoic acid (PFOA) is widely used throughout different industries, including the food industry, because it is resistant to heat and prevents water or oil from easily permeating into or contaminating materials coated by PFOA. Although many studies have reported an association between PFOA exposure and the risk of developing hepatic diseases, it is still in debate because they have shown conflicting results. Therefore, this study conducted a systematic review and meta-analysis on the relationship between PFOA exposure and hepatic diseases. Methods: This study searched studies related to hepatic diseases due to PFOA exposure until 31 December 2021, using PubMed, EMBASE, and Web of Science. This study performed a systematic review and meta-analysis through research question development, literature screening, data extraction, and risk of bias evaluation. This study found 8280 studies after excluding duplicate literature and selected 5 studies in the final stage. Among them, two studies were included in the meta-analysis. Results: The results of the meta-analysis showed that the ALT of people exposed to PFOA was 117% higher than the ALT of those not exposed to PFOA, and it was significantly different (OR = 1.167; 95% CI, 1.086–1.254). Conclusion: However, since the number of studies included in the analysis was not large enough to conclude that PFOA exposure was associated with the development of hepatic diseases, more observational studies are needed to confirm its long-term effects.

Suggested Citation

  • Jihee Choi & Jong-Yeon Kim & Hae-Jeung Lee, 2022. "Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(18), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11318-:d:910454
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    References listed on IDEAS

    as
    1. Siti Suhana Abdullah Soheimi & Amirah Abdul Rahman & Normala Abd Latip & Effendi Ibrahim & Siti Hamimah Sheikh Abdul Kadir, 2021. "Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study," IJERPH, MDPI, vol. 18(16), pages 1-22, August.
    2. Pingping Liu & Fang Yang & Yongbo Wang & Zhanpeng Yuan, 2018. "Perfluorooctanoic Acid (PFOA) Exposure in Early Life Increases Risk of Childhood Adiposity: A Meta-Analysis of Prospective Cohort Studies," IJERPH, MDPI, vol. 15(10), pages 1-14, September.
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    Cited by:

    1. Zhiqiang Zong & Mengjie Zhao & Mengyue Zhang & Kexin Xu & Yunquan Zhang & Xiujun Zhang & Chengyang Hu, 2022. "Association between PM 1 Exposure and Lung Function in Children and Adolescents: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-17, November.

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