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Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations

Author

Listed:
  • Felix Rafael De Bie

    (Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium)

  • David Basurto

    (Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium)

  • Sailesh Kumar

    (Mater Research Institute and School of Medicine, University of Queensland, Brisbane, QLD 4343, Australia)

  • Jan Deprest

    (Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium
    Department of Obstetrics and Gynecology, UZ Leuven, 3000 Leuven, Belgium)

  • Francesca Maria Russo

    (Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium
    Department of Obstetrics and Gynecology, UZ Leuven, 3000 Leuven, Belgium)

Abstract

Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology.

Suggested Citation

  • Felix Rafael De Bie & David Basurto & Sailesh Kumar & Jan Deprest & Francesca Maria Russo, 2022. "Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations," IJERPH, MDPI, vol. 19(18), pages 1-15, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11207-:d:908455
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    References listed on IDEAS

    as
    1. Mark Robert Dilworth & Irene Andersson & Lewis James Renshall & Elizabeth Cowley & Philip Baker & Susan Greenwood & Colin Peter Sibley & Mark Wareing, 2013. "Sildenafil Citrate Increases Fetal Weight in a Mouse Model of Fetal Growth Restriction with a Normal Vascular Phenotype," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-8, October.
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    Cited by:

    1. Karel Allegaert, 2022. "Pharmacotherapy during Pregnancy, Childbirth, and Lactation," IJERPH, MDPI, vol. 19(18), pages 1-5, September.

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