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Metformin and the Risk of Chronic Urticaria in Patients with Type 2 Diabetes

Author

Listed:
  • Fu-Shun Yen

    (Dr. Yen’s Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan 33354, Taiwan
    These authors contributed equally to this work.)

  • Chih-Cheng Hsu

    (Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
    Department of Health Services Administration, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
    Department of Family Medicine, Min-Sheng General Hospital, 168 ChingKuo Road, Taoyuan 33044, Taiwan
    National Center for Geriatrics and Welfare Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan)

  • Kai-Chieh Hu

    (Management Office for Health Data, China Medical University Hospital, 3F, No. 373-2, Jianxing Road, Taichung 40459, Taiwan
    College of Medicine, China Medical University, No. 91, Xueshi Road, Taichung 40202, Taiwan)

  • Yu-Tung Hung

    (Management Office for Health Data, China Medical University Hospital, 3F, No. 373-2, Jianxing Road, Taichung 40459, Taiwan
    College of Medicine, China Medical University, No. 91, Xueshi Road, Taichung 40202, Taiwan)

  • Chung Y. Hsu

    (Graduate Institute of Biomedical Sciences, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan)

  • James Cheng-Chung Wei

    (Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan
    Graduate Institute of Integrated Medicine, China Medical University, Taichung 40202, Taiwan)

  • Chii-Min Hwu

    (Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei 11221, Taiwan
    Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 11217, Taiwan)

Abstract

We conducted this study to determine the effect of metformin use on the risk of new-onset chronic urticaria in patients with type 2 diabetes (T2D). In total, 24,987 pairs of metformin users and nonusers were identified with propensity score-matching from Taiwan’s National Health Insurance Research Database from 1 January 2000, to 31 December 2017. Multivariable Cox proportional hazards models were used to compare the risks of chronic urticaria development, severe chronic urticaria, and hospitalization for chronic urticaria between metformin users and nonusers. Compared with metformin nonuse, the aHRs (95% CI) for metformin use in chronic urticaria development, severe chronic urticaria, and hospitalization for chronic urticaria were 1.56 (1.39–1.74), 0.40 (0.12–1.30), and 1.45 (0.82–2.56), respectively. The cumulative incidence of chronic urticaria development was significantly higher in metformin users than in nonusers ( p < 0.0001). A longer average cumulative duration of metformin use was associated with higher risks of new-onset and hospitalization for chronic urticaria than metformin nonuse. This nationwide cohort study showed that metformin use was associated with a significantly higher risk of chronic urticaria development. A longer average cumulative duration of metformin use was associated with a higher risk of outcomes. More prospective studies are needed to verify our results.

Suggested Citation

  • Fu-Shun Yen & Chih-Cheng Hsu & Kai-Chieh Hu & Yu-Tung Hung & Chung Y. Hsu & James Cheng-Chung Wei & Chii-Min Hwu, 2022. "Metformin and the Risk of Chronic Urticaria in Patients with Type 2 Diabetes," IJERPH, MDPI, vol. 19(17), pages 1-12, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:11045-:d:906131
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    References listed on IDEAS

    as
    1. Fu-Shun Yen & Chih-Cheng Hsu & Ying-Hsiu Shih & Wei-Lin Pan & James Cheng-Chung Wei & Chii-Min Hwu, 2022. "Metformin and the Development of Asthma in Patients with Type 2 Diabetes," IJERPH, MDPI, vol. 19(13), pages 1-13, July.
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