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Clinical, Laboratory, and Imaging Findings of Pregnant Women with Possible Vertical Transmission of SARS-CoV-2—Case Series

Author

Listed:
  • Marius Craina

    (Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
    Clinic of Obstetrics and Gynecology, County Clinical Emergency Hospital “Pius Brinzeu”, 300723 Timisoara, Romania)

  • Daniela Iacob

    (Department of Neonatology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania)

  • Mirabela Dima

    (Department of Neonatology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania)

  • Sandor Bernad

    (Romanian Academy Timisoara Branch, Mihai Viteazul Avenue, 24, 300275 Timisoara, Romania)

  • Carmen Silaghi

    (Clinic of Obstetrics and Gynecology, County Clinical Emergency Hospital “Pius Brinzeu”, 300723 Timisoara, Romania)

  • Andreea Moza

    (Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania)

  • Manuela Pantea

    (Department of Neonatology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania)

  • Adrian Gluhovschi

    (Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania)

  • Elena Bernad

    (Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
    Clinic of Obstetrics and Gynecology, County Clinical Emergency Hospital “Pius Brinzeu”, 300723 Timisoara, Romania)

Abstract

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic significantly impacted the general population’s health. At times, the infection has unfavorably influenced pregnancy evolution and the result of birth. However, vertical transmission of the virus is rare and generates controversial discussions. The study aimed to highlight the clinical, laboratory, and imaging findings of pregnant women with confirmed Coronavirus Disease 2019 (COVID-19) with possible vertical transmission and identify possible factors that encourage vertical transmission. Between 1 April 2020 and 31 December 2021, 281 pregnant women diagnosed with COVID-19 gave birth in the Obstetrics and Gynecology Departments of the tertiary unit of County Emergency Clinical Hospital from Timisoara. Three newborns (1.06%) tested positive. The characteristic of these three cases was described as a short series. In two cases, the patients were asymptomatic. In one case, the patient developed a mild form of COVID-19 with a favorable evolution in all cases. We did not identify the presence of smoking history, vaccine before admission, atypical presentation, fever, or chest X-ray abnormalities. We note possible factors that encourage vertical transmission: Pregnancy-induced hypertension, thrombophilia, asymptomatic cough, an asymptomatic or mild form of the disease, a ruptured membrane, and cesarean. The laboratory results highlight the inconstant presence of some changes found in the list of potential predictors of the severity of the infection: Lymphopenia, high values of C-reactive protein, D-dimer, fibrinogen, platelets, Aspartate Aminotransferase, Lactate dehydrogenase, and ferritin. The study’s conclusion of this small group suggests that there may have been an intrauterine infection in late pregnancy and described characteristics of the pregnant women. Possible risk factors that could encourage vertical transmission have been identified.

Suggested Citation

  • Marius Craina & Daniela Iacob & Mirabela Dima & Sandor Bernad & Carmen Silaghi & Andreea Moza & Manuela Pantea & Adrian Gluhovschi & Elena Bernad, 2022. "Clinical, Laboratory, and Imaging Findings of Pregnant Women with Possible Vertical Transmission of SARS-CoV-2—Case Series," IJERPH, MDPI, vol. 19(17), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10916-:d:904059
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    References listed on IDEAS

    as
    1. Sara Esteban-Gonzalo & María Caballero-Galilea & Juan Luis González-Pascual & Miguel Álvaro-Navidad & Laura Esteban-Gonzalo, 2021. "Anxiety and Worries among Pregnant Women during the COVID-19 Pandemic: A Multilevel Analysis," IJERPH, MDPI, vol. 18(13), pages 1-15, June.
    2. Urszula Nowacka & Szymon Kozlowski & Marcin Januszewski & Janusz Sierdzinski & Artur Jakimiuk & Tadeusz Issat, 2021. "COVID-19 Pandemic-Related Anxiety in Pregnant Women," IJERPH, MDPI, vol. 18(14), pages 1-10, July.
    Full references (including those not matched with items on IDEAS)

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