IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i17p10800-d901746.html
   My bibliography  Save this article

Economic Evaluations of Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A Systematic Review

Author

Listed:
  • Alessandra Castelluccia

    (Radiation Oncology, Department of Radiotherapy, Hospital “A. Perrino”, ASL Brindisi, 72100 Brindisi, Italy
    These authors contributed equally to this work.)

  • Pierpaolo Mincarone

    (Institute for Research on Population and Social Policies, National Research Council, 72100 Brindisi, Italy
    MOVE-Mentis s.r.l., 47522 Cesena, Italy
    These authors contributed equally to this work.)

  • Maria Rosaria Tumolo

    (Department of Biological and Environmental Sciences and Technology, University of Salento, 73100 Lecce, Italy)

  • Saverio Sabina

    (MOVE-Mentis s.r.l., 47522 Cesena, Italy
    Institute of Clinical Physiology, National Research Council, 73100 Lecce, Italy)

  • Riccardo Colella

    (Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy)

  • Antonella Bodini

    (Institute for Applied Mathematics and Information Technologies “E. Magenes”, National Research Council, 20133 Milan, Italy)

  • Francesco Tramacere

    (Radiation Oncology, Department of Radiotherapy, Hospital “A. Perrino”, ASL Brindisi, 72100 Brindisi, Italy)

  • Maurizio Portaluri

    (Radiation Oncology, Department of Radiotherapy, Hospital “A. Perrino”, ASL Brindisi, 72100 Brindisi, Italy)

  • Carlo Giacomo Leo

    (MOVE-Mentis s.r.l., 47522 Cesena, Italy
    Institute of Clinical Physiology, National Research Council, 73100 Lecce, Italy)

Abstract

Objectives: This review systematically summarizes the evidence on the economic impact of magnetic resonance image-guided RT (MRIgRT). Methods: We systematically searched INAHTA, MEDLINE, and Scopus up to March 2022 to retrieve health economic studies. Relevant data were extracted on study type, model inputs, modeling methods and economic results. Results: Five studies were included. Two studies performed a full economic assessment to compare the cost-effectiveness of MRIgRT with other forms of image-guided radiation therapy. One study performed a cost minimization analysis and two studies performed an activity-based costing, all comparing MRIgRT with X-ray computed tomography image-guided radiation therapy (CTIgRT). Prostate cancer was the target condition in four studies and hepatocellular carcinoma in one. Considering the studies with a full economic assessment, MR-guided stereotactic body radiation therapy was found to be cost effective with respect to CTIgRT or conventional or moderate hypofractionated RT, even with a low reduction in toxicity. Conversely, a greater reduction in toxicity is required to compete with extreme hypofractionated RT without MR guidance. Conclusions: This review highlights the great potential of MRIgRT but also the need for further evidence, especially for late toxicity, whose reduction is expected to be the real added value of this technology.

Suggested Citation

  • Alessandra Castelluccia & Pierpaolo Mincarone & Maria Rosaria Tumolo & Saverio Sabina & Riccardo Colella & Antonella Bodini & Francesco Tramacere & Maurizio Portaluri & Carlo Giacomo Leo, 2022. "Economic Evaluations of Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A Systematic Review," IJERPH, MDPI, vol. 19(17), pages 1-21, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10800-:d:901746
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/17/10800/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/17/10800/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Elahe Khorasani & Majid Davari & Abbas Kebriaeezadeh & Farshad Fatemi & Ali Akbari Sari & Vida Varahrami, 2022. "A comprehensive review of official discount rates in guidelines of health economic evaluations over time: the trends and roots," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(9), pages 1577-1590, December.
    2. Maarten J. IJzerman & Hendrik Koffijberg & Elisabeth Fenwick & Murray Krahn, 2017. "Emerging Use of Early Health Technology Assessment in Medical Product Development: A Scoping Review of the Literature," PharmacoEconomics, Springer, vol. 35(7), pages 727-740, July.
    3. Sorenson, Corinna & Drummond, Michael & Bhuiyan Kahn, Beena, 2013. "Medical technology as a key driver of rising health expenditures: disentangling the relationship," LSE Research Online Documents on Economics 48043, London School of Economics and Political Science, LSE Library.
    4. Karl Claxton & Mike Paulden & Hugh Gravelle & Werner Brouwer & Anthony J. Culyer, 2011. "Discounting and decision making in the economic evaluation of health‐care technologies," Health Economics, John Wiley & Sons, Ltd., vol. 20(1), pages 2-15, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chia-Chin Li & Ying-Chun Lin & Ji-An Liang & K. S. Clifford Chao & Te-Chun Hsia & Chun-Ru Chien, 2023. "Health Economic Evaluation of Proton Therapy for Lung Cancer: A Systematic Review," IJERPH, MDPI, vol. 20(6), pages 1-10, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hareth Al-Janabi & Job van Exel & Werner Brouwer & Joanna Coast, 2016. "A Framework for Including Family Health Spillovers in Economic Evaluation," Medical Decision Making, , vol. 36(2), pages 176-186, February.
    2. Anderson, Pippa & Webb, Philip & Groves, Sam, 2017. "Prioritisation of specialist health care services; not NICE, not easy but it can be done," Health Policy, Elsevier, vol. 121(9), pages 978-985.
    3. Emily Sinnott & Maurizio Bussolo & Johannes Koettl, 2015. "Golden Aging," World Bank Publications - Books, The World Bank Group, number 22018.
    4. Arthur E. Attema & Han Bleichrodt & Olivier L’Haridon & Patrick Peretti-Watel & Valérie Seror, 2018. "Discounting health and money: New evidence using a more robust method," Journal of Risk and Uncertainty, Springer, vol. 56(2), pages 117-140, April.
    5. Júlia Varga, 2017. "Out-migration and attrition of physicians and dentists before and after EU accession (2003 and 2011): the case of Hungary," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 18(9), pages 1079-1093, December.
    6. Carlo Lazzaro, 2025. "Letter to the Editor: Lazzaro responds to Kennedy et al," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 26(1), pages 141-142, February.
    7. Weatherly, Helen & Drummond, Michael & Claxton, Karl & Cookson, Richard & Ferguson, Brian & Godfrey, Christine & Rice, Nigel & Sculpher, Mark & Sowden, Amanda, 2009. "Methods for assessing the cost-effectiveness of public health interventions: Key challenges and recommendations," Health Policy, Elsevier, vol. 93(2-3), pages 85-92, December.
    8. Fan, Victoria Y. & Savedoff, William D., 2014. "The health financing transition: A conceptual framework and empirical evidence," Social Science & Medicine, Elsevier, vol. 105(C), pages 112-121.
    9. Seung-Lai Yoo & Dae-Jung Kim & Seung-Mi Lee & Won-Gu Kang & Sang-Yoon Kim & Jong Hyuk Lee & Dong-Churl Suh, 2019. "Improving Patient Access to New Drugs in South Korea: Evaluation of the National Drug Formulary System," IJERPH, MDPI, vol. 16(2), pages 1-15, January.
    10. Petra Marešová & Lukáš Peter & Jan Honegr & Lukáš Režný & Marek Penhaker & Martin Augustýnek & Hana Mohelská & Blanka Klímová & Kamil Kuča, 2020. "Complexity Stage Model of the Medical Device Development Based on Economic Evaluation—MedDee," Sustainability, MDPI, vol. 12(5), pages 1-27, February.
    11. Mike Paulden & Anthony J. Culyer, 2010. "Does Cost-Effectiveness Analysis Discriminate against Patients with Short Life Expectancy?," Working Paper series 41_10, Rimini Centre for Economic Analysis.
    12. Michael Spackman, 2013. "Government Time Discounting and Required Rates of Return: UK History and Current Issues," Economic Affairs, Wiley Blackwell, vol. 33(2), pages 190-206, June.
    13. Nader Jahanmehr & Atieh Sadat Bigdeli & Hedayat Salari & Hussein Mokarami & Soheila KhodaKarim & Soheila Damiri, 2019. "Analyzing inappropriate magnetic resonance imaging (MRI) prescriptions and resulting economic burden on patients suffering from back pain," International Journal of Health Planning and Management, Wiley Blackwell, vol. 34(4), pages 1437-1447, October.
    14. E. Wetering & E. Stolk & N. Exel & W. Brouwer, 2013. "Balancing equity and efficiency in the Dutch basic benefits package using the principle of proportional shortfall," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(1), pages 107-115, February.
    15. Pieter van Baal & Meg Perry‐Duxbury & Pieter Bakx & Matthijs Versteegh & Eddy van Doorslaer & Werner Brouwer, 2019. "A cost‐effectiveness threshold based on the marginal returns of cardiovascular hospital spending," Health Economics, John Wiley & Sons, Ltd., vol. 28(1), pages 87-100, January.
    16. Jonathan Dando & Maximilian Lebmeier, 2020. "A novel valuation model for medical intervention development based on progressive dynamic changes that integrates Health Technology Assessment outcomes with early-stage innovation and indication-speci," Journal of Innovation and Entrepreneurship, Springer, vol. 9(1), pages 1-28, December.
    17. Roberto Moro Visconti & Donato Morea, 2020. "Healthcare Digitalization and Pay-For-Performance Incentives in Smart Hospital Project Financing," IJERPH, MDPI, vol. 17(7), pages 1-25, March.
    18. MacNeil, Maggie & Koch, Melissa & Kuspinar, Ayse & Juzwishin, Don & Lehoux, Pascale & Stolee, Paul, 2019. "Enabling health technology innovation in Canada: Barriers and facilitators in policy and regulatory processes," Health Policy, Elsevier, vol. 123(2), pages 203-214.
    19. Victoria Fan and William Savedoff, 2014. "The Health Financing Transition: A Conceptual Framework and Empirical Evidence - Working Paper 358," Working Papers 358, Center for Global Development.
    20. Rachel A Archer & Ritika Kapoor & Wanrudee Isaranuwatchai & Yot Teerawattananon & Birgitte Giersing & Siobhan Botwright & Jos Luttjeboer & Raymond C W Hutubessy, 2020. "‘It takes two to tango’: Bridging the gap between country need and vaccine product innovation," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-11, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10800-:d:901746. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.