IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i17p10586-d897090.html
   My bibliography  Save this article

Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham’s Chorea: A Multicenter Prospective Study

Author

Listed:
  • Alessandro Orsini

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Thomas Foiadelli

    (Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy)

  • Attilio Sica

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Andrea Santangelo

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Niccolò Carli

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Alice Bonuccelli

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Rita Consolini

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Sofia D’Elios

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Nicolò Loddo

    (Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy)

  • Alberto Verrotti

    (Department of Pediatrics, University of Perugia, 06123 Perugia, Italy)

  • Giuseppe Di Cara

    (Department of Pediatrics, University of Perugia, 06123 Perugia, Italy)

  • Chiara Marra

    (Child Neurology Unit, University of Bologna, 40126 Bologna, Italy)

  • Maria Califano

    (Child Neurology Unit, University of Bologna, 40126 Bologna, Italy)

  • Anna Fetta

    (Child Neurology Unit, University of Bologna, 40126 Bologna, Italy)

  • Marianna Fabi

    (Child Neurology Unit, University of Bologna, 40126 Bologna, Italy)

  • Stefania Bergamoni

    (Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, 20121 Milan, Italy)

  • Aglaia Vignoli

    (Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, 20121 Milan, Italy
    Health Sciences Department, Università degli Studi di Milano, 20121 Milan, Italy)

  • Roberta Battini

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
    Department of Developmental Neuroscience, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Fondazione Stella Maris, 56121 Pisa, Italy)

  • Marta Mosca

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

  • Chiara Baldini

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

  • Nadia Assanta

    (Heart Hospital, G. Monasterio Tuscan Foundation, 54100 Massa, Italy)

  • Pietro Marchese

    (Heart Hospital, G. Monasterio Tuscan Foundation, 54100 Massa, Italy)

  • Gabriele Simonini

    (Pediatric Rheumatology, Meyer Children Hospital, University of Florence, 50134 Florence, Italy)

  • Edoardo Marrani

    (Pediatric Rheumatology, Meyer Children Hospital, University of Florence, 50134 Florence, Italy)

  • Francesca Felicia Operto

    (Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy)

  • Grazia Maria Giovanna Pastorino

    (Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy)

  • Salvatore Savasta

    (Pediatric Clinic, ASST di Crema, 26013 Crema, Italy)

  • Giuseppe Santangelo

    (Child Neuropsychiatry Unit, ISMEP—P.O. Cristina—ARNAS Civico, Via dei Benedettini 1, 90100 Palermo, Italy)

  • Virginia Pedrinelli

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

  • Gabriele Massimetti

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

  • Liliana Dell’Osso

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

  • Diego Peroni

    (Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy)

  • Duccio Maria Cordelli

    (Child Neurology Unit, University of Bologna, 40126 Bologna, Italy)

  • Martina Corsi

    (Occupational Health Department, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124 Pisa, Italy)

  • Claudia Carmassi

    (Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy)

Abstract

Sydenham’s chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12–15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC’s onset. Our population was divided in a SC group (n = 21), consisting of patients who had SC, and a nSC group (n = 27), consisting of patients who had ARF without SC. Both groups were evaluated by the administration of 8 different neuropsychiatric tests. The Work and Social Adjustment Scale (WSAS) showed significantly ( p = 0.021) higher alterations in the SC group than in the nSC group. Furthermore, 60.4% (n = 29) of the overall population experienced neuropsychiatric symptoms other than choreic movements at diagnosis and this finding was significantly more common ( p = 0.00) in SC patients (95.2%) than in nSC patients (33.3%). The other neuropsychiatric tests also produced significant results, indicating that SC can exert a strong psychopathological impact on patients even years after its onset.

Suggested Citation

  • Alessandro Orsini & Thomas Foiadelli & Attilio Sica & Andrea Santangelo & Niccolò Carli & Alice Bonuccelli & Rita Consolini & Sofia D’Elios & Nicolò Loddo & Alberto Verrotti & Giuseppe Di Cara & Chiar, 2022. "Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham’s Chorea: A Multicenter Prospective Study," IJERPH, MDPI, vol. 19(17), pages 1-13, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10586-:d:897090
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/17/10586/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/17/10586/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10586-:d:897090. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.