IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i16p10406-d893896.html
   My bibliography  Save this article

Findings and Outcome of Transcatheter Right Ventricular Endomyocardial Biopsy and Hemodynamic Assessment in Children with Suspected Myocarditis or Cardiomyopathy

Author

Listed:
  • Alessia Callegari

    (Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland)

  • Daniel Quandt

    (Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland)

  • Achim Schmitz

    (Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland
    Division of Anesthesia, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Karin Klingel

    (Cardiopathology, Institute for Pathology, Eberhard Karls University Tübingen, 72074 Tubingen, Germany)

  • Christian Balmer

    (Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland)

  • Hitendu Dave

    (Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland
    Congenital Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Oliver Kretschmar

    (Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland
    These authors contributed equally to this paper.)

  • Walter Knirsch

    (Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Children’s Research Centre, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University of Zurich, 8006 Zurich, Switzerland
    These authors contributed equally to this paper.)

Abstract

Objective: The study objective is assessing findings and outcome in children with suspected cardiomyopathy (CMP) or myocarditis undergoing cardiac catheterization with transcatheter right ventricular endomyocardial biopsy (RV-EMB). Methods: All consecutive children undergoing cardiac catheterization with RV-EMB for suspected CMP/myocarditis between 2002–2021 were analysed regarding clinical presentation, cardiac biomarkers, periprocedural management, hemodynamic, histological/immunohistological findings, and outcome. Results: Eighty-five RV-EMBs were performed in 81 patients at a median age of 6.8 (IQR 9.9) years and a bodyweight of 20 (32.2) kg. Histological/immunohistological findings of RV-EMB revealed dilated CMP in 10 (12%), chronic myocarditis in 28 (33%), healing myocarditis in 5 (6%), acute myocarditis in 9 (11%), other heart muscle diseases in 23 (27%) (7 restrictive CMP, 5 hypertrophic CMP, 4 toxic/anthracycline-induced CMP, 4 endocardfibroelastosis, 1 arrhythmogenic right ventricular CMP, 1 laminin CMP, 1 haemangioma), no conclusive histology in 7 (8%), and normal histology in 3 (4%) patients. Median LVEDP was 17 mmHg (IQR 9), LAP 15 mmHg (10), and PVR 1.83 (1.87) Wood Units/m 2 . There were 3 major complications (3%), all patients recovered without any sequelae. At follow-up (median 1153, IQR 1799 days) 47 (59%) patients were alive, 11 (13%) dead, 15 (18%) underwent cardiac transplantation, and 8 (9%) were lost to follow-up. Death/cardiac transplantation occurred within 3 years from RV-EMB. All patients with an acute myocarditis survived. NT-pro-BNP, echo parameters, and invasive hemodynamics correlate independently with death/cardiac transplant. Conclusion: Hemodynamic invasive data and morphological findings in RV-EMB complete clinical diagnosis in children with suspected CMP/myocarditis and provide important information for further clinical management.

Suggested Citation

  • Alessia Callegari & Daniel Quandt & Achim Schmitz & Karin Klingel & Christian Balmer & Hitendu Dave & Oliver Kretschmar & Walter Knirsch, 2022. "Findings and Outcome of Transcatheter Right Ventricular Endomyocardial Biopsy and Hemodynamic Assessment in Children with Suspected Myocarditis or Cardiomyopathy," IJERPH, MDPI, vol. 19(16), pages 1-13, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10406-:d:893896
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/16/10406/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/16/10406/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10406-:d:893896. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.