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Endometrial Cancer in Aspect of Forkhead Box Protein Contribution

Author

Listed:
  • Olga Adamczyk-Gruszka

    (Department of Gynaecology and Obstetrics, Collegium Medicum, Jan Kochanowski University, 25-369 Kielce, Poland
    Department of Obstetrics and Gynaecology, Province Hospital, 25-369 Kielce, Poland)

  • Agata Horecka-Lewitowicz

    (Institute of Health Sciences, Jan Kochanowski University, 25-369 Kielce, Poland)

  • Jakub Gruszka

    (2nd Department of Obstetrics and Gynaecology, Medical University of Warsaw, 02-091 Warsaw, Poland)

  • Monika Wawszczak-Kasza

    (Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, 25-369 Kielce, Poland)

  • Agnieszka Strzelecka

    (Institute of Health Sciences, Jan Kochanowski University, 25-369 Kielce, Poland)

  • Piotr Lewitowicz

    (Department of Clinical and Experimental Pathology, Institute of Medical Sciences, Jan Kochanowski University, 25-369 Kielce, Poland)

Abstract

(1) Background: The present study aimed to investigate the influence of forkhead box (FOX) on endometrial cancer (EC) progression. For a better understanding, the driving mechanisms are vital to identifying correlations between genes and their regulators. (2) Methods: The study enrolled one hundred and three white female patients with confirmed EC. For the analysis, we used next-generation sequencing with the Hot Spot Cancer Panel provided by Illumina Inc., San Diego, CA, USA, and an immunohistochemical analysis of FOXA1, FOXP1, and estrogen receptors. (3) Results: FOXA1 silencing led to a worse outcome based on the correlation with FOXA1 (test log-rank p = 0.04220 and HR 2.66, p = 0.033). Moreover, FOX proteins were closely correlated with TP53 and KRAS mutation. (4) Conclusions: Our study confirmed previous reports about FOX box protein in the regulation of tumor growth. A remarkable observation about the unclear crosstalk with crucial genes, as TP53 and KRAS need deeper investigation.

Suggested Citation

  • Olga Adamczyk-Gruszka & Agata Horecka-Lewitowicz & Jakub Gruszka & Monika Wawszczak-Kasza & Agnieszka Strzelecka & Piotr Lewitowicz, 2022. "Endometrial Cancer in Aspect of Forkhead Box Protein Contribution," IJERPH, MDPI, vol. 19(16), pages 1-7, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10403-:d:893741
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    References listed on IDEAS

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    1. Douglas A. Levine, 2013. "Integrated genomic characterization of endometrial carcinoma," Nature, Nature, vol. 497(7447), pages 67-73, May.
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