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Perfluorooctanoic Acid Affects Thyroid Follicles in Common Carp ( Cyprinus carpio )

Author

Listed:
  • Maurizio Manera

    (Faculty of Biosciences, Food and Environmental Technologies, University of Teramo, St. R. Balzarini 1, 64100 Teramo, Italy)

  • Giuseppe Castaldelli

    (Department of Environmental and Prevention Sciences, University of Ferrara, St. Borsari 46, 44121 Ferrara, Italy)

  • Luisa Giari

    (Department of Environmental and Prevention Sciences, University of Ferrara, St. Borsari 46, 44121 Ferrara, Italy)

Abstract

Carp kidney is comprised of nephrons, hemopoietic tissue, and also hormonally-active thyroid follicles. Given this anatomical trait, it has been used to assess the thyroid disrupting potential of perfluorooctanoic acid (PFOA), a widespread and feared per- poly-fluoroalkyl substance and a persistent organic pollutant capable of interfering with the endocrine system in animals and humans. The occurrence and morphology of thyroid follicles in kidneys of carp experimentally exposed to 200 ng L −1 or 2 mg L −1 waterborne PFOA for 56 days were studied. The abundance of thyroid follicles was significantly higher and vesiculation increased in exposed fish as compared to controls. The number of vesiculated follicles/total number of follicles was positively correlated with PFOA blood concentration in fish exposed to the highest dose (2 mg L −1 ). The structure and ultrastructure of thyroid follicles were affected by PFOA also at the lower, environmentally relevant, concentration (200 ng L −1 ). Increased cellular projections, enhanced colloid endocytosis, rough endoplasmic reticulum enlargement and fragmentation and cytoplasm vacuolation were the main features displayed by PFOA-exposed carp. These results show that PFOA affects the occurrence and status of follicles and suggest the utility of fish kidney as a multipurpose biomarker organ in environmental pathology research, according to the One Health approach.

Suggested Citation

  • Maurizio Manera & Giuseppe Castaldelli & Luisa Giari, 2022. "Perfluorooctanoic Acid Affects Thyroid Follicles in Common Carp ( Cyprinus carpio )," IJERPH, MDPI, vol. 19(15), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9049-:d:871395
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    References listed on IDEAS

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    1. Maurizio Manera & Bahram Sayyaf Dezfuli & Giuseppe Castaldelli & Joseph A. DePasquale & Elisa Anna Fano & Camillo Martino & Luisa Giari, 2019. "Perfluorooctanoic Acid Exposure Assessment on Common Carp Liver through Image and Ultrastructural Investigation," IJERPH, MDPI, vol. 16(24), pages 1-15, December.
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    Cited by:

    1. Maurizio Manera & Fabio Casciano & Luisa Giari, 2023. "Ultrastructural Alterations of the Glomerular Filtration Barrier in Fish Experimentally Exposed to Perfluorooctanoic Acid," IJERPH, MDPI, vol. 20(7), pages 1-12, March.

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