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Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

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  • Takumi Watanabe

    (Division of Translational Research, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi 329-0498, Tochigi, Japan
    College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai 487-8501, Aichi, Japan)

  • Kyoko Hayashi

    (College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai 487-8501, Aichi, Japan)

  • Tsuyoshi Takara

    (Medical Corporation Seishinkai, Takara Clinic, 2-3-2-9, Higashigotanda, Shinagawa 141-0022, Tokyo, Japan)

  • Takumi Teratani

    (Division of Translational Research, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi 329-0498, Tochigi, Japan)

  • Joji Kitayama

    (Division of Translational Research, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi 329-0498, Tochigi, Japan)

  • Toshio Kawahara

    (College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai 487-8501, Aichi, Japan)

Abstract

Mouse studies have reported anti-stress effects of Lactiplantibacillus plantarum SNK12 (SNK). Specifically, oral SNK administration increased mRNA levels of hippocampal neurotrophic factor and gamma-aminobutyric acid receptor in mice with sub-chronic mild stress-induced social defeat; moreover, it improved depressive behavior. We aimed to evaluate the efficacy of SNK ingestion against stress in healthy adults. We used the Uchida–Kraepelin test for the stress load, with a low-dose (50 mg/day), high-dose (150 mg/day), and placebo groups (dextrin). The primary outcome was the psychological evaluation as measured by the Profile of Mood States 2nd Edition (POMS2) using total mood disturbance (TMD) scores. The secondary outcomes were the score of each POMS2 item, salivary cortisol as a stress marker, and autonomic balance with the low frequency (LF)/ high frequency (HF) ratio. Compared with the placebo group, the SNK ingestion group showed significantly lower TMD scores. Additionally, compared with the placebo group, the high-dose group showed significantly lower scores for Tension-Anxiety and Confusion-Bewilderment, while the low-dose group showed significantly lower Anger-Hostility scores, salivary cortisol levels, and LF/HF scores. Our findings suggest that SNK ingestion could relieve stress (negative feelings, anxiety, tension, embarrassment, confusion, anger, and hostility) resulting from the temporary load caused by work and study.

Suggested Citation

  • Takumi Watanabe & Kyoko Hayashi & Tsuyoshi Takara & Takumi Teratani & Joji Kitayama & Toshio Kawahara, 2022. "Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study," IJERPH, MDPI, vol. 19(15), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:8936-:d:869547
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    References listed on IDEAS

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    1. Suni Lee & Shoko Yamamoto & Naoko Kumagai-Takei & Nagisa Sada & Kei Yoshitome & Yasumitsu Nishimura & Toshihiro Kojima & Takemi Otsuki, 2019. "Didgeridoo Health Promotion Method Improves Mood, Mental Stress, and Stability of Autonomic Nervous System," IJERPH, MDPI, vol. 16(18), pages 1-17, September.
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