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The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea

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  • SuHyun Lee

    (Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea
    Department of Public Health, Graduate School, Yonsei University, Seoul 03722, Korea)

  • YoungWook Lim

    (Institute for Environmental Research, Yonsei University College of Medicine, Seoul 03722, Korea)

  • YounSeok Kang

    (Environment Testing Division, Eurofins Korea Ltd., Gunpo 15849, Korea)

  • KeumJi Jung

    (Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea)

  • SunHa Jee

    (Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea
    Department of Public Health, Graduate School, Yonsei University, Seoul 03722, Korea)

Abstract

Background and Objectives: Epidemiological studies have inconsistently shown an association between dioxin and risk of type 2 diabetes mellitus (T2DM) and cancer. This study aims to examine the effects of blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) on T2DM and thyroid cancer. Methods: We conducted a nested case–control study within the Korean cancer prevention study-II (KCPS-II) consisting of 15 thyroid cancer cases, 30 T2DM cases, and 55 controls. A total of 500 samples were used in 100 pooling samples. An average value of a pooled sample was calculated weighted by the blood volume of each sample. Results: The study population included 100 participants from the KCPS-II (median (IQR) baseline age, 54.06 [21.04] years; 48 women). The toxic equivalents of PCDD/DFs showed a significant positive association with T2DM and thyroid cancer, after adjustments for potential confounders (T2DM ORs = 1.23; 95% CI = 1.05–1.43; thyroid cancer ORs = 1.34; 95% CI = 1.12–1.61). Conclusion: In this study, both T2DM and thyroid cancer were associated with the blood concentrations of PCDD/DFs. The association between PCDD/DFs and T2D was found among women but not among men. Our findings suggest that further biochemical in vivo research and epidemiologic studies are needed to clarify the association between dioxins concentrations and diseases.

Suggested Citation

  • SuHyun Lee & YoungWook Lim & YounSeok Kang & KeumJi Jung & SunHa Jee, 2022. "The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea," IJERPH, MDPI, vol. 19(14), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8745-:d:865642
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    References listed on IDEAS

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    1. Carla Reale & Filomena Russo & Sara Carmela Credendino & Danila Cuomo & Gabriella De Vita & Massimo Mallardo & Francesca Pennino & Immacolata Porreca & Maria Triassi & Mario De Felice & Concetta Ambro, 2019. "A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis," IJERPH, MDPI, vol. 16(1), pages 1-17, January.
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    Cited by:

    1. Ladan Rokni & Mehdi Rezaei & Mahdi Rafieizonooz & Elnaz Khankhajeh & Ali Akbar Mohammadi & Shahabaldin Rezania, 2023. "Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases," Sustainability, MDPI, vol. 15(14), pages 1-19, July.

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