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RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity

Author

Listed:
  • Max Lenz

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria
    Ludwig Boltzmann Cluster for Cardiovascular Research, 1090 Vienna, Austria)

  • Robert Schönbauer

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

  • Stefan Stojkovic

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

  • Jonghui Lee

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

  • Constantin Gatterer

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

  • Michael Lichtenauer

    (Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria)

  • Vera Paar

    (Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria)

  • Michael Emich

    (Austrian Federal Ministry of Defence, Austrian Armed Forces, 1090 Vienna, Austria)

  • Monika Fritzer-Szekeres

    (Chemical Laboratory Analysis, Department of Medical, Medical University of Vienna, 1090 Vienna, Austria)

  • Jeanette Strametz-Juranek

    (Rehabilitation Centre Bad Tatzmannsdorf, 7431 Bad Tatzmannsdorf, Austria)

  • Senta Graf

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

  • Michael Sponder

    (Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria)

Abstract

Regular physical exercise was found to be associated with an improved immune response in previous studies. RANTES and CD40L play a pivotal role in host defense, and individuals lacking adequate expression are prone to virus and opportunistic infections. A total of 98 participants were enrolled in this study. The probands were asked to perform moderate physical activity, and bicycle stress tests were performed at the baseline and after 8 months of training to evaluate individual performance. RANTES and CD40L were found to be increased by long-term physical exercise. In particular, probands with a performance gain of ≥3% displayed a pronounced elevation of both markers, paired with a decrease in circulating IL6 levels and an improved lipid profile. In summary, we were able to highlight rising levels of serum RANTES and CD40L under the conditions of physical exercise. Taking their role in host defense into account, a conjunction of physical activity and the adaptive immune system could therefore be assumed. Furthermore, low inflammatory profiles in probands with a significant performance gain suggest a modulation through exercise rather than a generalized pro-inflammatory status.

Suggested Citation

  • Max Lenz & Robert Schönbauer & Stefan Stojkovic & Jonghui Lee & Constantin Gatterer & Michael Lichtenauer & Vera Paar & Michael Emich & Monika Fritzer-Szekeres & Jeanette Strametz-Juranek & Senta Graf, 2022. "RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity," IJERPH, MDPI, vol. 19(14), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8658-:d:864170
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    Keywords

    sport; training; CCL5; sCD40L; inflammation; immune system; 2022;
    All these keywords.

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