IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i13p8145-d854609.html
   My bibliography  Save this article

Impacts of Antibiotic Residues in the Environment on Bacterial Resistance and Human Health in Eastern China: An Interdisciplinary Mixed-Methods Study Protocol

Author

Listed:
  • Shenghan Cai

    (Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK
    These authors contributed equally to this work.)

  • Na Wang

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
    These authors contributed equally to this work.)

  • Like Xu

    (Department of Chemistry, University of Bath, Bath BA2 7AY, UK)

  • Fei Yan

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200032, China)

  • Qingwu Jiang

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China)

  • Xinping Zhao

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200032, China)

  • Wei Wang

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200032, China)

  • Hexing Wang

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China)

  • Lufang Jiang

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China)

  • Wenjuan Cong

    (Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK)

  • Samuel K. Sheppard

    (The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Department of Zoology, University of Oxford, Oxford OX1 2JD, UK)

  • Jason Weeks

    (IEH Consulting, Nottingham NG2 6AU, UK)

  • Barbara Kasprzyk-Hordern

    (Department of Chemistry, University of Bath, Bath BA2 7AY, UK)

  • Chaowei Fu

    (Key Laboratory of Public Health Safety of Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Shanghai 200032, China
    Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200032, China)

  • Helen Lambert

    (Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK)

Abstract

Antibiotic resistance is a global health challenge that threatens human and animal lives, especially among low-income and vulnerable populations in less-developed countries. Its multi-factorial nature requires integrated studies on antibiotics and resistant bacteria in humans, animals, and the environment. To achieve a comprehensive understanding of the situation and management of antibiotic use and environmental transmission, this paper describes a study protocol to document human exposure to antibiotics from major direct and indirect sources, and its potential health outcomes. Our mixed-methods approach addresses both microbiological and pathogen genomics, and epidemiological, geospatial, anthropological, and sociological aspects. Implemented in two rural residential areas in two provinces in Eastern China, linked sub-studies assess antibiotic exposure in population cohorts through household surveys, medicine diaries, and biological sampling; identify the types and frequencies of antibiotic resistance genes in humans and food-stock animals; quantify the presence of antibiotic residues and antibiotic resistance genes in the aquatic environment, including wastewater; investigate the drivers and behaviours associated with human and livestock antibiotic use; and analyse the national and local policy context, to propose strategies and systematic measurements for optimising and monitoring antibiotic use. As a multidisciplinary collaboration between institutions in the UK and China, this study will provide an in-depth understanding of the influencing factors and allow comprehensive awareness of the complexity of AMR and antibiotic use in rural Eastern China.

Suggested Citation

  • Shenghan Cai & Na Wang & Like Xu & Fei Yan & Qingwu Jiang & Xinping Zhao & Wei Wang & Hexing Wang & Lufang Jiang & Wenjuan Cong & Samuel K. Sheppard & Jason Weeks & Barbara Kasprzyk-Hordern & Chaowei , 2022. "Impacts of Antibiotic Residues in the Environment on Bacterial Resistance and Human Health in Eastern China: An Interdisciplinary Mixed-Methods Study Protocol," IJERPH, MDPI, vol. 19(13), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8145-:d:854609
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/13/8145/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/13/8145/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Helen Lambert & Meixuan Chen & Christie Cabral, 2019. "Antimicrobial resistance, inflammatory responses: a comparative analysis of pathogenicities, knowledge hybrids and the semantics of antibiotic use," Palgrave Communications, Palgrave Macmillan, vol. 5(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jinxin Zang & Lufang Jiang & Yingying Wang & Yue Chen & Chaowei Fu & Barbara Kasprzyk-Hordern & Na Wang & Qingwu Jiang & Helen Lambert, 2024. "Impact of easing COVID-19 restrictions on antibiotic usage in Eastern China using wastewater-based epidemiology," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Carla F. Rodrigues, 2020. "Self-medication with antibiotics in Maputo, Mozambique: practices, rationales and relationships," Palgrave Communications, Palgrave Macmillan, vol. 6(1), pages 1-12, December.
    2. Lenore Manderson, 2020. "Prescribing, care and resistance: antibiotic use in urban South Africa," Palgrave Communications, Palgrave Macmillan, vol. 7(1), pages 1-10, December.
    3. Samuel O. Abimbola & Melvine Anyango Otieno & Jennifer Cole, 2021. "Reducing the Use of Antimicrobials as a Solution to the Challenge of Antimicrobial Resistance (AMR): Approaching an Ethical Dilemma through the Lens of Planetary Health," Challenges, MDPI, vol. 12(2), pages 1-12, September.
    4. Osborne, Jacob & Paget, John & Giles-Vernick, Tamara & Kutalek, Ruth & Napier, David & Baliatsas, Christos & Dückers, Michel, 2021. "Community engagement and vulnerability in infectious diseases: A systematic review and qualitative analysis of the literature," Social Science & Medicine, Elsevier, vol. 284(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8145-:d:854609. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.