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Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle

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  • Yoshikuni Sugimura

    (Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
    Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

  • Akira Kanda

    (Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan)

  • Kaori Sawada

    (Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

  • Kyi Mar Wai

    (Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

  • Asano Tanabu

    (Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

  • Naoki Ozato

    (Health & Wellness Products Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan)

  • Tatsuyuki Midorikawa

    (Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
    Research and Development Headquarters, Lion Corporation, Odawara 256-0811, Japan)

  • Takayoshi Hisada

    (TechnoSuruga Laboratory Co., Ltd., 388-1 Nagasaki, Shimizu-ku, Shizuoka 424-0065, Japan)

  • Shigeyuki Nakaji

    (Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
    Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

  • Kazushige Ihara

    (Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan)

Abstract

This study aimed to investigate the gut microbial genera associated with skeletal muscle mass, using a large-scale survey from the standpoint of preventing sarcopenia. A total of 848 participants were included in the analysis. The mean (SD) ages of men ( n = 353) and women ( n = 495) were 50.0 (12.9) years and 50.8 (12.8) years, respectively. Body composition was assessed using appendicular skeletal muscle mass/body weight (ASM/BW), ASM, and BW. Additionally, the relationship between gut microbial genera and body composition was analyzed. The means (SD) of ASM/BW were 34.9 (2.4) % in men and 29.4 (2.9) % in women. Blautia and Bifidobacterium were positively associated with ASM/BW only in men ( Blautia : β = 0.0003, Bifidobacterium : β = 0.0001). However, Blautia was negatively associated with BW (β = −0.0017). Eisenbergiella was positively associated with ASM/BW (β = 0.0209) and negatively associated with BW (β = −0.0769) only in women. Our results indicate that Blautia , Bifidobacterium and Eisenbergiella , which are positively associated with ASM/BW, might help increase skeletal muscle mass. ASM/BW may clarify the relationship between gut microbiota and skeletal muscle mass without being affected by obesity or excess body fat mass.

Suggested Citation

  • Yoshikuni Sugimura & Akira Kanda & Kaori Sawada & Kyi Mar Wai & Asano Tanabu & Naoki Ozato & Tatsuyuki Midorikawa & Takayoshi Hisada & Shigeyuki Nakaji & Kazushige Ihara, 2022. "Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle," IJERPH, MDPI, vol. 19(12), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7464-:d:841684
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    References listed on IDEAS

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    1. Hitomi Maruta & Hiromi Yamashita, 2020. "Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-19, September.
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    1. Ayushi Trivedi & Dipro Bose & Kelly Moffat & Elisabeth Pearson & Dana Walsh & Devra Cohen & Jonathan Skupsky & Linda Chao & Julia Golier & Patricia Janulewicz & Kimberly Sullivan & Maxine Krengel & As, 2024. "Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort," IJERPH, MDPI, vol. 21(8), pages 1-22, August.

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