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Tetracyclines—An Important Therapeutic Tool for Dermatologists

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  • Malgorzata Orylska-Ratynska

    (Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland)

  • Waldemar Placek

    (Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland)

  • Agnieszka Owczarczyk-Saczonek

    (Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland)

Abstract

Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years, the most characteristic and important ones in daily dermatological practice being: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, and idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss the instances where the efficacy and safety of tetracyclines have been highlighted over the past few years.

Suggested Citation

  • Malgorzata Orylska-Ratynska & Waldemar Placek & Agnieszka Owczarczyk-Saczonek, 2022. "Tetracyclines—An Important Therapeutic Tool for Dermatologists," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7246-:d:837925
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    References listed on IDEAS

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    1. Nicholas Joza & Santos A. Susin & Eric Daugas & William L. Stanford & Sarah K. Cho & Carol Y. J. Li & Takehiko Sasaki & Andrew J. Elia & H.-Y. Mary Cheng & Luigi Ravagnan & Karine F. Ferri & Naoufal Z, 2001. "Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death," Nature, Nature, vol. 410(6828), pages 549-554, March.
    2. Santos A. Susin & Hans K. Lorenzo & Naoufal Zamzami & Isabel Marzo & Bryan E. Snow & Greg M. Brothers & Joan Mangion & Etienne Jacotot & Paola Costantini & Markus Loeffler & Nathanael Larochette & Dav, 1999. "Molecular characterization of mitochondrial apoptosis-inducing factor," Nature, Nature, vol. 397(6718), pages 441-446, February.
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