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Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

Author

Listed:
  • Chenwei Pan

    (School of Public Health, Medical College of Soochow University, Suzhou 215123, China
    These authors contributed equally to this work.)

  • Huijuan Zhao

    (Key Laboratory of Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, No. 130 Dongan Road, Shanghai 200032, China
    Key Laboratory of Health Technology Assessment, National Health Commission of the People’s Republic of China, Fudan University, Shanghai 200032, China
    These authors contributed equally to this work.)

  • Qiaoling Du

    (Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China
    These authors contributed equally to this work.)

  • Yong Xu

    (School of Public Health, Medical College of Soochow University, Suzhou 215123, China)

  • Dajun Tian

    (Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Ave, St. Louis, MO 63104, USA)

  • Shuo Xiao

    (Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Environmental and Occupational Health Sciences Institutes, Rutgers University, Piscataway, NJ 08854, USA)

  • Haiyin Wang

    (Department of Health Technology Assessment, Shanghai Health Development Research Center, Shanghai 200032, China)

  • Xiao Wei

    (Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Chunfeng Wu

    (Shanghai Municipal Center for Disease Control & Prevention, No. 1380 West Zhongshan Road, Shanghai 200336, China)

  • Yuanyuan Ruan

    (NHC Key Laboratory of Glycoconjugates Research, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China)

  • Chunhua Zhao

    (Education and Training Department, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China
    Technology Department, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 26 Daoqian Street, Suzhou 215001, China)

  • Gonghua Tao

    (Shanghai Municipal Center for Disease Control & Prevention, No. 1380 West Zhongshan Road, Shanghai 200336, China)

  • Weiwei Zheng

    (Key Laboratory of Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, No. 130 Dongan Road, Shanghai 200032, China
    Key Laboratory of Health Technology Assessment, National Health Commission of the People’s Republic of China, Fudan University, Shanghai 200032, China)

Abstract

Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants ( p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.

Suggested Citation

  • Chenwei Pan & Huijuan Zhao & Qiaoling Du & Yong Xu & Dajun Tian & Shuo Xiao & Haiyin Wang & Xiao Wei & Chunfeng Wu & Yuanyuan Ruan & Chunhua Zhao & Gonghua Tao & Weiwei Zheng, 2022. "Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:6958-:d:832930
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    References listed on IDEAS

    as
    1. Briana N Sprague & Christine B Phillips & Lesley A Ross, 2019. "Age-Varying Relationships Between Physical Function and Cognition in Older Adulthood," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 74(5), pages 772-784.
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