IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i11p6912-d832035.html
   My bibliography  Save this article

Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship

Author

Listed:
  • Francesca Gorini

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Laura Sabatino

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Alessio Coi

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Giorgio Iervasi

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Cristina Vassalle

    (Fondazione CNR-Regione Toscana Gabriele Monasterio, 56124 Pisa, Italy)

Abstract

COVID-19 represents a worldwide public health emergency, and, beyond the respiratory symptoms characterizing the classic viral disease, growing evidence has highlighted a possible reciprocal relationship between SARS-CoV-2 infection and thyroid dysfunction. The updated data discussed in this review suggests a role of SARS-CoV-2 infection on the thyroid gland, with multiple thyroid pictures described. Conversely, no conclusion can be drawn on the association between pre-existing thyroid disease and increased risk of SARS-CoV-2 infection. In this scenario, selenium (Se), an essential trace element critical for thyroid function and known as an effective agent against viral infections, is emerging as a potential novel therapeutic option for the treatment of COVID-19. Large multicentre cohort studies are required to elucidate the mechanisms underlying thyroid dysfunction during or following recovery from COVID-19, including Se status. Meanwhile, clinical trials should be performed to evaluate whether adequate intake of Se can help address COVID-19 in Se-deficient patients, also avoiding thyroid complications that can contribute to worsening outcomes during infection.

Suggested Citation

  • Francesca Gorini & Laura Sabatino & Alessio Coi & Giorgio Iervasi & Cristina Vassalle, 2022. "Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship," IJERPH, MDPI, vol. 19(11), pages 1-24, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6912-:d:832035
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/11/6912/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/11/6912/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Francesca Gorini & Cristina Vassalle, 2023. "A Literature Review on SARS-CoV-2 and Other Viruses in Thyroid Disorders: Environmental Triggers or No-Guilty Bystanders?," IJERPH, MDPI, vol. 20(3), pages 1-21, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6912-:d:832035. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.