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Laccase–TEMPO as an Efficient System for Doxorubicin Removal from Wastewaters

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  • Luiza Izabela Jinga

    (Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri, 050663 Bucharest, Romania
    National Institute for Lasers, Plasma and Radiation Physics, Atomistilor 409, 077125 Magurele, Romania)

  • Madalina Tudose

    (Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania)

  • Petre Ionita

    (Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri, 050663 Bucharest, Romania)

Abstract

A large number of drugs are used to treat different diseases, and thus to improve the quality of life for humans. These represent a real ecological threat, as they end up in soil or ground waters in amounts that can affect the environment. Among these drugs, doxorubicin is a highly cytotoxic compound used as anticancer medicine. Doxorubicin can be efficiently removed from wastewater or polluted water using a simple enzymatic (biocatalytic) system, employing the oxidoreductase enzyme laccase and a stable organic nitroxide-free radical, TEMPO. Results presented in this work (as percentage of removal) were obtained at pH 5 and 7, after 2, 4, 6, and 24 h, using different ratios between doxorubicin, laccase, and TEMPO. It was shown that longer time, as well as an increased amount of catalyst, led to a higher percentage of removal, up to 100%. The influence of all these parameters is also discussed. In this way it was shown that the laccase–TEMPO biocatalytic system is highly efficient in the removal of the anticancer drug doxorubicin from wastewaters.

Suggested Citation

  • Luiza Izabela Jinga & Madalina Tudose & Petre Ionita, 2022. "Laccase–TEMPO as an Efficient System for Doxorubicin Removal from Wastewaters," IJERPH, MDPI, vol. 19(11), pages 1-8, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6645-:d:827337
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    References listed on IDEAS

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    1. Andreia D. M. Silva & Juliana Sousa & Malin Hultberg & Sónia A. Figueiredo & Olga M. Freitas & Cristina Delerue-Matos, 2022. "Fluoxetine Removal from Aqueous Solutions Using a Lignocellulosic Substrate Colonized by the White-Rot Fungus Pleurotus ostreatus," IJERPH, MDPI, vol. 19(5), pages 1-16, February.
    2. Laura N. Levin & Carlos E. Hernández-Luna & Guillermo Niño-Medina & Juan Pablo García-Rodríguez & Iosvany López-Sadin & Gerardo Méndez-Zamora & Guadalupe Gutiérrez-Soto, 2019. "Decolorization and Detoxification of Synthetic Dyes by Mexican Strains of Trametes sp," IJERPH, MDPI, vol. 16(23), pages 1-13, November.
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