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Serum Ketone Levels May Correspond with Preoperative Body Weight Loss in Patients Undergoing Elective Surgery: A Single-Center, Prospective, Observational Feasibility Study

Author

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  • Paweł Kutnik

    (II Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland)

  • Michał Borys

    (II Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland)

  • Grzegorz Buszewicz

    (Laboratory of Forensic Toxicology, Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland)

  • Paweł Piwowarczyk

    (II Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland)

  • Marcin Osak

    (Laboratory of Forensic Toxicology, Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland)

  • Grzegorz Teresiński

    (Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland)

  • Mirosław Czuczwar

    (II Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland)

Abstract

Although nutritional-risk scoring systems allow the determination of the patient’s malnutrition at admission, additional tools might be useful in some clinical scenarios. Previous medical history could be unavailable in unconscious or demented patients. This study aimed to assess the ketone bodies serum levels in patients undergoing elective surgeries and to determine the possible correlation between ketone bodies serum levels and preoperative body weight loss. The study included 21 patients who underwent elective surgery. Hyperketonemia, defined as ketone bodies over 1 mmol/L, was observed in seven (33.3%) patients. Patients with hyperketonemia had significantly higher preoperative percentage body weight loss ( p = 0.04) and higher nutritional risk scores prior to surgery ( p = 0.04). Serum glucose and the percentage of body weight loss were associated with increased ketone bodies serum levels (Odds Ratios: 0.978 (0.961–0.996, p = 0.019) and 1.222 (1.0–1.492, p = 0.05), respectively). A significant linear correlation was found between the percentage of body weight loss and both ketones bodies (r 2 = 0.25, p = 0.02) and albumin serum levels (r 2 = 0.19, p = 0.04). Our study’s results might suggest a positive association between preoperative body weight loss and ketone bodies serum levels. The observation between increased ketone bodies serum levels in patients and preoperative body mass loss merits further research.

Suggested Citation

  • Paweł Kutnik & Michał Borys & Grzegorz Buszewicz & Paweł Piwowarczyk & Marcin Osak & Grzegorz Teresiński & Mirosław Czuczwar, 2022. "Serum Ketone Levels May Correspond with Preoperative Body Weight Loss in Patients Undergoing Elective Surgery: A Single-Center, Prospective, Observational Feasibility Study," IJERPH, MDPI, vol. 19(11), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6573-:d:826329
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    References listed on IDEAS

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    1. Frank L Forcino & Lindsey R Leighton & Pamela Twerdy & James F Cahill, 2015. "Reexamining Sample Size Requirements for Multivariate, Abundance-Based Community Research: When Resources are Limited, the Research Does Not Have to Be," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-18, June.
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