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The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study

Author

Listed:
  • Jou-Yu Lin

    (Department of Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan
    These authors contributed equally to this work.)

  • Che-Se Tung

    (Division of Medical Research & Education, Cheng Hsin General Hospital, Taipei 11220, Taiwan
    These authors contributed equally to this work.)

  • Jen-Chun Wang

    (Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Wu-Chien Chien

    (Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
    Taiwanese Injury Prevention and Safety Promotion Association, Taipei 11490, Taiwan)

  • Chi-Hsiang Chung

    (Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
    Taiwanese Injury Prevention and Safety Promotion Association, Taipei 11490, Taiwan)

  • Chih-Yuan Lin

    (Department of Surgery, Division of Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Shih-Hung Tsai

    (Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei 11490, Taiwan)

Abstract

Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.

Suggested Citation

  • Jou-Yu Lin & Che-Se Tung & Jen-Chun Wang & Wu-Chien Chien & Chi-Hsiang Chung & Chih-Yuan Lin & Shih-Hung Tsai, 2021. "The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 18(8), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4389-:d:539995
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    References listed on IDEAS

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    1. Chun-Pai Yang & Meng-Lun Hsieh & Jen-Huai Chiang & Hsing-Yi Chang & Vivian Chia-Rong Hsieh, 2017. "Migraine and risk of narcolepsy in children: A nationwide longitudinal study," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-13, December.
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