IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i8p4020-d534242.html
   My bibliography  Save this article

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Author

Listed:
  • Thung-Lip Lee

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan)

  • Chin-Feng Hsuan

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
    Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, Kaohsiung 80794, Taiwan)

  • Cheng-Ching Wu

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan)

  • Wei-Chin Hung

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan)

  • I-Ting Tsai

    (School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
    Department of Emergency, E-Da Hospital, Kaohsiung 82445, Taiwan)

  • Ching-Ting Wei

    (School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
    Division of General Surgery, Department of Surgery, E-Da Hospital, Kaohsiung 82445, Taiwan
    Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan
    Department of Electrical Engineering, I-Shou University, Kaohsiung 82445, Taiwan)

  • Teng-Hung Yu

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan)

  • I-Cheng Lu

    (Department of Occupational Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan)

  • Fu-Mei Chung

    (Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan)

  • Yau-Jiunn Lee

    (Lee’s Endocrinologic Clinic, Pingtung 90000, Taiwan)

  • Yung-Chuan Lu

    (School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
    Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan)

Abstract

Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers.

Suggested Citation

  • Thung-Lip Lee & Chin-Feng Hsuan & Cheng-Ching Wu & Wei-Chin Hung & I-Ting Tsai & Ching-Ting Wei & Teng-Hung Yu & I-Cheng Lu & Fu-Mei Chung & Yau-Jiunn Lee & Yung-Chuan Lu, 2021. "Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers," IJERPH, MDPI, vol. 18(8), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4020-:d:534242
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/8/4020/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/8/4020/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Tomohide Yamada & Kazuo Hara & Takashi Kadowaki, 2013. "Chewing Betel Quid and the Risk of Metabolic Disease, Cardiovascular Disease, and All-Cause Mortality: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-10, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wei-Chin Hung & Teng-Hung Yu & Cheng-Ching Wu & Thung-Lip Lee & Wei-Hua Tang & Chia-Chi Chen & I-Cheng Lu & Fu-Mei Chung & Yau-Jiunn Lee & Chia-Chang Hsu, 2022. "Nonalcoholic Fatty Liver Disease Is Related to Abnormal Corrected QT Interval and Left Ventricular Hypertrophy in Chinese Male Steelworkers," IJERPH, MDPI, vol. 19(21), pages 1-15, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yu-Chung Tsao & Wen-Cheng Li & Wei-Chung Yeh & Steve Wen-Neng Ueng & Sherry Yueh-Hsia Chiu & Jau-Yuan Chen, 2020. "The Association between Metabolic Syndrome and Related Factors among the Community-Dwelling Indigenous Population in Taiwan," IJERPH, MDPI, vol. 17(23), pages 1-14, December.
    2. Suzanne M. de la Monte & Natalia Moriel & Amy Lin & Nada Abdullah Tanoukhy & Camille Homans & Gina Gallucci & Ming Tong & Ayumi Saito, 2020. "Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations," IJERPH, MDPI, vol. 17(18), pages 1-21, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4020-:d:534242. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.