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New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors

Author

Listed:
  • Kacper Packi

    (Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland
    Kacper Packi and Joanna Matysiak contributed equally to this work.)

  • Joanna Matysiak

    (Faculty of Health Sciences, Calisia University, 62-800 Kalisz, Poland
    Kacper Packi and Joanna Matysiak contributed equally to this work.)

  • Eliza Matuszewska

    (Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland)

  • Anna Bręborowicz

    (Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, Poland)

  • Zdzisława Kycler

    (Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, Poland)

  • Jan Matysiak

    (Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland)

Abstract

Hymenoptera venom allergy significantly affects the quality of life. Due to the divergences in the results of the available test and clinical symptoms of patients, the current widely applied diagnostic methods are often insufficient to classify patients for venom immunotherapy (VIT). Therefore it is still needed to search for new, more precise, and accurate diagnostic methods. Hence, this research aimed to discover new biomarkers of Hymenoptera venom allergy in a group of inflammation factors using set of multi-marker Bioplex panel. The adoption of a novel methodology based on Luminex/xMAP enabled simultaneous determination of serum levels of 37 different inflammatory proteins in one experiment. The study involved 21 patients allergic to wasp and/or honey bee venom and 42 healthy participants. According to univariate and multivariate statistics, soluble CD30/tumor necrosis factor receptor superfamily, member 8 (sCD30/TNFRSF8), and the soluble tumor necrosis factor receptor 1 (sTNF-R1) may be considered as effective prognostic factors, their circulating levels were significantly decreased in the allergy group ( p -value < 0.05; the Area Under the Curve (AUC) ~0.7; Variable Importance in Projection (VIP) scores >1.2). The obtained results shed new light on the allergic inflammatory response and may contribute to modification and improvement of the diagnostic and monitoring methods. Further, large-scale studies are still needed to explain mechanisms of action of studied compounds and to definitively prove their usefulness in clinical practice.

Suggested Citation

  • Kacper Packi & Joanna Matysiak & Eliza Matuszewska & Anna Bręborowicz & Zdzisława Kycler & Jan Matysiak, 2021. "New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors," IJERPH, MDPI, vol. 18(8), pages 1-20, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4011-:d:534068
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    Cited by:

    1. Kacper Packi & Joanna Matysiak & Sylwia Klimczak & Eliza Matuszewska & Anna Bręborowicz & Dagmara Pietkiewicz & Jan Matysiak, 2022. "Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy," IJERPH, MDPI, vol. 19(13), pages 1-22, June.

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