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The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study

Author

Listed:
  • Artur Niedzielski

    (Clinic of Pediatric Otolaryngology, Center of Postgraduate Medical Education (CMKP), 01-813 Warsaw, Poland
    Independent Otoneurological Laboratory, Medical University of Lublin, 20-093 Lublin, Poland)

  • Lechosław Paweł Chmielik

    (Clinic of Pediatric Otolaryngology, Center of Postgraduate Medical Education (CMKP), 01-813 Warsaw, Poland)

  • Tomasz Stankiewicz

    (Independent Otoneurological Laboratory, Medical University of Lublin, 20-093 Lublin, Poland)

Abstract

Background: Otitis media with effusion (OME) can cause serious complications such as hearing impairment or development delays. The aim of the study was to assess the microbiological profile of organisms responsible for OME and to determine if a biofilm formation can be observed. Methods: Ninety-nine samples from 76 patients aged from 6 months to 12 years were collected for microbiological and molecular studies. Results: In microbiological studies, pathogenic bacteria Haemophilus influenzae (38.89%), Streptococcus pneumoniae (33.33%), and Staphylococcus aureus MSSA (27.78%), as well as opportunistic bacteria Staphylococcus spp. (74.14%), Diphtheroids (20.69%), Streptococcus viridans (3.45%), and Neisseria spp. (1.72%) were found. The average degree of hearing loss in the group of children with positive bacterial culture was 35.9 dB, while in the group with negative bacterial culture it was 25.9 dB ( p = 0.0008). The type of cultured bacteria had a significant impact on the degree of hearing impairment in children ( p = 0.0192). In total, 37.5% of Staphylococcus spp. strains were able to form biofilm. Conclusions: Staphylococcus spp. in OME may form biofilms, which can explain the chronic character of the disease. Pathogenic and opportunistic bacteria may be involved in the etiopathogenesis of OME. The degree of hearing loss was significantly higher in patients from which the positive bacterial cultures were obtained.

Suggested Citation

  • Artur Niedzielski & Lechosław Paweł Chmielik & Tomasz Stankiewicz, 2021. "The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study," IJERPH, MDPI, vol. 18(7), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:7:p:3555-:d:526369
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