IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i6p3012-d517228.html
   My bibliography  Save this article

Prenatal Exposure to Parabens Affects Birth Outcomes through Maternal Glutathione S-Transferase (GST) Polymorphisms: From the Mothers and Kids Environmental Health (MAKE) Study

Author

Listed:
  • Bohye Shin

    (Department of Population Health Sciences, Faculty of Life Sciences & Medicine, King’s College London, London WC2R 2LS, UK
    These authors are considered as joint first authors.)

  • Jeoung A. Kwon

    (Institute of Health Services Research, Yonsei University, Seoul 03722, Korea
    These authors are considered as joint first authors.)

  • Eun Kyo Park

    (Department of Occupational and Environmental Medicine, Ewha Medical Research Institute, Seoul 07804, Korea)

  • Sora Kang

    (Department of Medical Informatics, School of Medicine, Ajou University, Suwon 16499, Korea)

  • Seyoung Kim

    (Division of Cancer Prevention and Early Detection, National Cancer Control Institute, Cancer Center, Goyang 10408, Korea)

  • Eunyoung Park

    (Division of Cancer Prevention and Early Detection, National Cancer Control Institute, Cancer Center, Goyang 10408, Korea)

  • Byungmi Kim

    (Division of Cancer Prevention and Early Detection, National Cancer Control Institute, Cancer Center, Goyang 10408, Korea)

Abstract

Introduction: Human exposure to parabens is very common in daily life, and prenatal exposure to these chemicals is associated with poor birth outcomes. Therefore, the aim of this study was to investigate the effect of glutathione S-transferase (GST) polymorphisms on the association between prenatal exposure to parabens and birth outcomes. Methods: We conducted a multivariate analysis involving 177 subjects to determine the association between paraben concentrations and birth outcomes in mothers with GST mu 1 (GSTM1) and GST theta 1 (GSTT1) polymorphisms from 2017 to 2019. Furthermore, we determined the interactive effect between paraben levels and GSTM1/GSTT1 polymorphisms using regression analysis, in addition to a generalized linear model after stratifying GSTM1/GSTT1 genotype into three categories. Results: Methyl and propyl paraben concentrations were significantly and positively associated with birth weight (methyl, β = 116.525, 95% confidence interval (CI) = 22.460–210.590; propyl, β = 82.352, 95% CI = 9.147–155.557) in individuals with the GSTM1-null genotype. Moreover, the propyl paraben concentration was significantly associated with an increase in gestational age (β = 0.312, 95% CI = 0.085–0.539) in individuals with the GSTM1-null genotype. Conclusions: This study reported the association between prenatal paraben exposure and birth outcomes in individuals with GST polymorphisms. We found positive relationships of maternal exposure to methyl parabens with birth weight in both mothers with GSTM1 and GSTT1-null genotypes.

Suggested Citation

  • Bohye Shin & Jeoung A. Kwon & Eun Kyo Park & Sora Kang & Seyoung Kim & Eunyoung Park & Byungmi Kim, 2021. "Prenatal Exposure to Parabens Affects Birth Outcomes through Maternal Glutathione S-Transferase (GST) Polymorphisms: From the Mothers and Kids Environmental Health (MAKE) Study," IJERPH, MDPI, vol. 18(6), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3012-:d:517228
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/6/3012/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/6/3012/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Asta Danileviciute & Regina Grazuleviciene & Jone Vencloviene & Algimantas Paulauskas & Mark J. Nieuwenhuijsen, 2012. "Exposure to Drinking Water Trihalomethanes and Their Association with Low Birth Weight and Small for Gestational Age in Genetically Susceptible Women," IJERPH, MDPI, vol. 9(12), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Keywords

      birth weight; GSTM1; GSTT1; parabens; polymorphism;
      All these keywords.

      JEL classification:

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3012-:d:517228. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.